Alcohol consumption and gastric cancer risk—A pooled analysis within the StoP project consortium

Roberto Persiani, Stefania Boccia, Nuno Miguel De Sousa Lunet, Pagona Lagiou, Matteo Rota, Claudio Pelucchi, Paola Bertuccio, Keitaro Matsuo, Zuo-Feng Zhang, Hidemi Ito, Jinfu Hu, Kenneth C. Johnson, Domenico Palli, Monica Ferraroni, Guo-Pei Yu, Joshua Muscat, Nuno Lunet, Bárbara Peleteiro, Weimin Ye, Huan SongDavid Zaridze, Dmitry Maximovitch, Marcela Guevara, Tania Fernández-Villa, Jesus Vioque, Eva M. Navarrete-Muñoz, Alicja Wolk, Nicola Orsini, Andrea Bellavia, Niclas Håkansson, Lina Mu, Robert C. Kurtz, Areti Lagiou, Carlotta Galeone, Rossella Bonzi, Paolo Boffetta, Eva Negri, Carlo La Vecchia

Risultato della ricerca: Contributo in rivistaArticolo in rivista

44 Citazioni (Scopus)

Abstract

An association between heavy alcohol drinking and gastric cancer risk has been recently reported, but the issue is still open to discussion and quantification. We investigated the role of alcohol drinking on gastric cancer risk in the “Stomach cancer Pooling (StoP) Project,” a consortium of epidemiological studies. A total of 9,669 cases and 25,336 controls from 20 studies from Europe, Asia and North America were included. We estimated summary odds-ratios (ORs) and the corresponding 95% confidence intervals (CIs) by pooling study-specific ORs using random-effects meta-regression models. Compared with abstainers, drinkers of up to 4 drinks/day of alcohol had no increase in gastric cancer risk, while the ORs were 1.26 (95% CI, 1.08–1.48) for heavy (>4 to 6 drinks/day) and 1.48 (95% CI 1.29–1.70) for very heavy (>6 drinks/day) drinkers. The risk for drinkers of >4 drinks/day was higher in never smokers (OR 1.87, 95% CI 1.35–2.58) as compared with current smokers (OR 1.14, 95% CI 0.93–1.40). Somewhat stronger associations emerged with heavy drinking in cardia (OR 1.61, 95% CI 1.11–2.34) than in non-cardia (OR 1.28, 95% CI 1.13–1.45) gastric cancers, and in intestinal-type (OR 1.54, 95% CI 1.20–1.97) than in diffuse-type (OR 1.29, 95% CI 1.05–1.58) cancers. The association was similar in strata of H. pylori infected (OR = 1.52, 95% CI 1.16–2.00) and noninfected subjects (OR = 1.69, 95% CI 0.95–3.01). Our collaborative pooled-analysis provides definite, more precise quantitative evidence than previously available of an association between heavy alcohol drinking and gastric cancer risk.
Lingua originaleEnglish
pagine (da-a)1950-1962
Numero di pagine13
RivistaInternational Journal of Cancer
Volume141
DOI
Stato di pubblicazionePubblicato - 2017

Keywords

  • Stomach Neoplasms
  • alcohol drinking
  • case-control studies
  • gastric cancer
  • pooled analysis
  • risk factors

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