Agomelatine increases BDNF serum levels in depressed patients in correlation with the improvement of depressive symptoms

Luigi Janiri, Giovanni Martinotti, Mauro Pettorruso, Valerio Ricci, Marco Di Nicola, Massimo Di Giannantonio, Domenico De Berardis, Paola Annunziata Varasano, Gabriella Lucidi Pressanti, Valeria De Remigis, Alessandro Valchera, Giovanni Biggio

Risultato della ricerca: Contributo in rivistaArticolo in rivista

39 Citazioni (Scopus)

Abstract

Background: Agomelatine modulates brain-derived neurotrophic factor expression via its interaction with melatonergic and serotonergic receptors and has shown promising results in terms of brain-derived neurotrophic factor increase in animal models. Methods: Twenty-seven patients were started on agomelatine (25 mg/d). Venous blood was collected and brain-derived neurotrophic factor serum levels were measured at baseline and after 2 and 8 weeks along with a clinical assessment, including Hamilton Depression Rating Scale and Snaith-Hamilton Pleasure Scale. Results: Brain-derived neurotrophic factor serum concentration increased after agomelatine treatment. Responders showed a significant increase in brain-derived neurotrophic factor levels after 2 weeks of agomelatine treatment; no difference was observed in nonresponders. Linear regression analysis showed that more prominent brain-derived neurotrophic factor level variation was associated with lower baseline BDNF levels and greater anhedonic features at baseline. Conclusions: Patients affected by depressive disorders showed an increase of brain-derived neurotrophic factor serum concentration after a 2-week treatment with agomelatine. The increase of brain-derived neurotrophic factor levels was found to be greater in patients with lower brain-derived neurotrophic factor levels and marked anhedonia at baseline.
Lingua originaleEnglish
pagine (da-a)pyw003-N/A
RivistaInternational Journal of Neuropsychopharmacology
Volume19
DOI
Stato di pubblicazionePubblicato - 2016

Keywords

  • Agomelatine
  • BDNF
  • Major depressive disorder
  • Pharmacology
  • Pharmacology (medical)
  • Psychiatry and Mental Health

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