Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients: EPICOVIDEHA findings

Giuseppe Rossi, Jon Salmanton-García, Chiara Cattaneo, Francesco Marchesi, Julio Dávila-Valls, Sonia Martín-Pérez, Federico Itri, Alberto López-García, Andreas Glenthøj, Maria Gomes Da Silva, Caroline Besson, Monia Marchetti, Barbora Weinbergerová, Ozren Jaksic, Moraima Jiménez, Yavuz M. Bilgin, Jaap Van Doesum, Francesca Farina, Pavel Ak, Luisa VergaGraham P. Collins, Valentina Bonuomo, Jens Van Praet, Marcio Nucci, Stef Meers, Ildefonso Espigado, Nicola S. Fracchiolla, Toni Valkovic, Christian Bjørn Poulsen, Natasha Colovic, Giulia Dragonetti, Marie-Pierre Ledoux, Carlo Tascini, Caterina Buquicchio, Ola Blennow, Francesco Passamonti, Marina Machado, Jorge Labrador, Rafael F. Duarte, Martin Schönlein, Lucia Prezioso, Iker Falces-Romero, Austin Kulasekararaj, Carolina Garcia-Vidal, Noemí Fernández, Ghaith Abu-Zeinah, Irati Ormazabal-Vélez, Tatjana Ad Ic-Vukicevic, Klára Piukovics, Igor Stoma, Annarosa Cuccaro, Gabriele Magliano, Tomá Szotkowski, Tomás-José González-López, Shaimaa El-Ashwah, Rui Bergantim, Uluhan Sili, Johan Maertens, Fatih Demirkan, Cristina De Ramón, Verena Petzer, Maria Ilaria Del Principe, Milan Navrátil, Michelina Dargenio, Guldane Cengiz Seval, Michail Samarkos, Zdenek Rácil, László Imre Pinczés, Tobias Lahmer, Alessandro Busca, Gustavo-Adolfo Méndez, Antonio Vena, Monika M. Biernat, Maria Merelli, Maria Calbacho, Aleksandra Barac, Martina Bavastro, Alessandro Limongelli, Osman Ilhan, Dominik Wolf, Gökçe Melis Çolak, Ramón García-Sanz, Ziad Emarah, Bojana Mi Kovic, Stefanie K. Gräfe, Milo Mladenovic, Tommaso Francesco Aiello, Lucía Núñez-Martín-Buitrago, Anna Nordlander, Elena Arellano, Giovanni Paolo Maria Zambrotta, Emanuele Ammatuna, Alba Cabirta, Maria Vittoria Sacchi, Raquel Nunes Rodrigues, Ditte Stampe Hersby, Michaela Hanakova, Laman Rahimli, Raul Cordoba, Oliver A. Cornely, Livio Pagano, Marques De Almeida, Hernández-Rivas, Joyce Marques De Almeida, José-Ángel Hernández-Rivas, Anna Guidetti, Olimpia Finizio, Zlate Stojanoski, Milche Cvetanoski, Joseph Meletiadis, Nick De Jonge, Darko Antic, Natasha Ali, Maria Chiara Tisi, Laura Serrano, Gaëtan Plantefeve, Nina Khanna, Martin Hoenigl, Martin Cernan, Carolina Miranda-Castillo, María Fernández-Galán, Alexandra Serris, Nurettin Erben, Rémy Duléry, Avinash Aujayeb, Mario Virgilio Papa, Jan Novák, Mario Delia, Giuseppe Sapienza, Florian Reizine, Ali S. Omrani, Roberta Di Blasi, Sylvain Lamure, Lubo Drgona, Nicola Coppola, Josip Batinic, Murtadha Al-Khabori, José-María Ribera-Santa Susana, Monica Piedimonte, Jorge Loureiro-Amigo, Guillemette Fouquet, Rita Fazzi, François Danion, Jörg Schubert, Baerbel Hoell-Neugebauer, Nathan C. Bahr, Ayel Omar Yahia, Ana Torres-Atienza, Ikhwan Rinaldi, Marina Popova, Hans-Beier Ommen, Maria Enza Mitra, Malgorzata Mikulska, Ira Lacej, Sofya Khostelidi, Sein Win, Donald Vinh, Modar Saleh, Juergen Prattes, Pavel Jindra, Fabio Guolo, Roberta Della Pepa, Ekaterina Chelysheva, Przemyslaw Zdziarski, Vivien Wai-Man, Andrés Soto-Silva, Hans Martin Orth, Sandra Malak, Lisset Lorenzo De La Pena, Martin Kolditz, Chi Shan Kho, Christopher H. Heath, Ana Groh, Eleni Gavriilaki, Monica Fung, Matthias Egger, Elizabeth De Kort, Erik De Cabo, Tania Cushion, Fazle Rabbi Chowdhury, M. Mansour Ceesay, Mathias Brehon, Gina Varricchio, Agostino Tafuri, María-Josefa Jiménez-Lorenzo, Nikolai Klimko, Panagiotis Tsirigotis, Anastasia Antoniadou, Maria Vehreschild

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Objectives: Elderly patients with hematologic malignancies face the highest risk of severe COVID-19 outcomes. The infection's impact on different age groups remains unstudied in detail. Methods: We analyzed elderly patients (age groups: 65-70, 71-75, 76-80, and >80 years old) with hematologic malignancies included in the EPICOVIDEHA registry between January 2020 and July 2022. Univariable and multivariable Cox regression models were conducted to identify factors influencing death in COVID-19 patients with hematological malignancy. Results: The study included data from 3,603 elderly patients (aged 65 or older) with hematological malignancy, with a majority being male (58.1%) and a significant proportion having comorbidities. The patients were divided into four age groups, and the analysis assessed COVID-19 outcomes, vaccination status, and other variables in relation to age and pandemic waves. The 90-day survival rate for patients with COVID-19 was 71.2%, with significant differences between groups. The pandemic waves had varying impacts, with the first wave affecting patients over 80 years old, the second being more severe in 65-70, and the third being the least severe in all age groups. Factors contributing to 90-day mortality included age, comorbidities, lymphopenia, active malignancy, acute leukemia, less than three vaccine doses, severe COVID-19, and using only corticosteroids as treatment. Conclusion: These data underscore the heterogeneity of elderly hematological patients, highlight the different impacts of COVID-19 waves and the pivotal importance of vaccination, and may help in planning future healthcare efforts.
Lingua originaleEnglish
pagine (da-a)98-110
Numero di pagine13
RivistaInternational Journal of Infectious Diseases
Volume137
DOI
Stato di pubblicazionePubblicato - 2023

Keywords

  • COVID-19
  • Elderly
  • Hematological malignancy
  • High-risk patient
  • SARS-CoV-2

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