Abstract
The stria vascularis (SV) of 3-, 8- and 18-month-old C57 mice was examined with a fluorescence microscope in order to evaluate the capillary density and vessel diameter. The capillary density was significantly reduced in 18-month-old mice compared to 3-month-old (P<0.001) and to 8-month-old (.P<0.001) mice. The difference between 3- and 18-month-old mice was significant for the basal, middle and apical cochlear turns, while the difference between 8- and 18-month-old mice was significant only for the middle and basal turns. Vessel diameter within the whole SV was significantly reduced in all turns in 18-month-old mice (P<0.01) versus 3-month-old animals, while vessel diameter was reduced only in the basal turn in 8-month-old versus 3-month-old mice. The results suggest that previously described histopathological changes in the organ of Corti of C57 mice may be related to modifications of strial capillaries.
Lingua originale | English |
---|---|
pagine (da-a) | 322-326 |
Numero di pagine | 5 |
Rivista | Audiology |
Volume | 2001 |
DOI | |
Stato di pubblicazione | Pubblicato - 2001 |
Keywords
- Capillary density
- Capillary diameter
- Cochlea
- Presbyacusis
- Stria vascularis