Advances in understanding - genetic basis of intellectual disability

Pietro Chiurazzi, Filomena Pirozzi

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

54 Citazioni (Scopus)

Abstract

Intellectual disability is the most common developmental disorder characterized by a congenital limitation in intellectual functioning and adaptive behavior. It often co-occurs with other mental conditions like attention deficit/hyperactivity disorder and autism spectrum disorder, and can be part of a malformation syndrome that affects other organs. Considering the heterogeneity of its causes (environmental and genetic), its frequency worldwide varies greatly. This review focuses on known genes underlying (syndromic and non-syndromic) intellectual disability, it provides a succinct analysis of their Gene Ontology, and it suggests the use of transcriptional profiling for the prioritization of candidate genes.
Lingua originaleEnglish
pagine (da-a)599-N/A
Numero di pagine16
RivistaF1000Research
Volume5
DOI
Stato di pubblicazionePubblicato - 2016

Keywords

  • Biochemistry, Genetics and Molecular Biology (all)
  • Immunology and Microbiology (all)
  • Medicine (all)
  • Pharmacology, Toxicology and Pharmaceutics (all)

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