Advanced Age and Medication Prescription: More Years, Less Medications? A Nationwide Report From the Italian Medicines Agency

Graziano Onder, Alessandra Marengoni, Pierluigi Russo, Luca Degli Esposti, Massimo Fini, Alessandro Monaco, Stefano Bonassi, Katie Palmer, Walter Marrocco, Giuseppe Pozzi, Diego Sangiorgi, Stefano Buda, Niccolò Marchionni, Federica Mammarella, Roberto Bernabei, Luca Pani, Sergio Pecorelli

Risultato della ricerca: Contributo in rivistaArticolo in rivista

23 Citazioni (Scopus)


Background: In older adults co-occurrence of multiple diseases often leads to use of multiple medications (polypharmacy). The aim of the present study is to describe how prescription of medications varies across age groups, with specific focus on the oldest old. Methods: We performed a cross-sectional study using 2013 data from the OsMed Health-DB database (mean number of medicines and defined daily doses prescribed in 15,931,642 individuals). There were 3,378,725 individuals age 65 years or older (21.2% of the study sample). Results: The mean number of prescribed medications progressively rose from 1.9 in the age group <65 years to 7.4 in the age group 80-84 years and then declined, with a more marked reduction in the age group 95 years or older with a mean number of 2.8 medications. A similar pattern was observed for the mean number of defined daily doses. Among participants age ≥65 years, proton pump inhibitors were the most commonly prescribed medication (40.9% of individuals ≥65 years), followed by platelet aggregation inhibitors (32.8%) and hydroxy-methylglutaryl-coenzyme A reductase inhibitors (26.1%). A decline in prescription was observed among individuals age 90 years or older, but this reduction was less consistent for medications used to treat acute conditions (ie, antibiotics and glucocorticoids) rather than preventive medicines commonly used to treat chronic diseases (ie, antihypertensive medications and hydroxy-methylglutaryl-coenzyme A reductase inhibitors). Conclusions: The burden of medication treatment progressively increases till age 85 and substantially declines after age of 90 years. Patterns of medication prescription widely vary across age groups.
Lingua originaleEnglish
pagine (da-a)168-172
Numero di pagine5
RivistaJournal of the American Medical Directors Association
Stato di pubblicazionePubblicato - 2016


  • Age Distribution
  • Aged
  • Aged, 80 and over
  • Cross-Sectional Studies
  • Databases, Factual
  • Drug Prescriptions
  • End of life
  • Female
  • Health Policy
  • Humans
  • Italy
  • Male
  • Medicine (all)
  • Nursing (all)2901 Nursing (miscellaneous)
  • Polypharmacy
  • Prescribing
  • Terminal Care


Entra nei temi di ricerca di 'Advanced Age and Medication Prescription: More Years, Less Medications? A Nationwide Report From the Italian Medicines Agency'. Insieme formano una fingerprint unica.

Cita questo