TY - JOUR
T1 - Adult-onset Still’s disease: an Italian multicentre retrospective observational study of manifestations and treatments in 245 patients
AU - Sfriso, Paolo
AU - Priori, Roberta
AU - Valesini, Guido
AU - Rossi, Silvia
AU - Montecucco, Carlo Maurizio
AU - D’Ascanio, Anna
AU - Carli, Linda
AU - Bombardieri, Stefano
AU - Laselva, Gaetana
AU - Iannone, Florenzo
AU - Lapadula, Giovanni
AU - Alivernini, Stefano
AU - Ferraccioli, Gianfranco
AU - Colaci, Michele
AU - Ferri, Clodoveo
AU - Iacono, Daniela
AU - Valentini, Gabriele
AU - Costa, Luisa
AU - Scarpa, Raffaele
AU - Lomonaco, Andrea
AU - Bagnari, Valentina
AU - Govoni, Marcello
AU - Piazza, Ilaria
AU - Adami, Silvano
AU - Ciccia, Francesco
AU - Triolo, Giovanni
AU - Alessandri, Elisa
AU - Cutolo, Maurizio
AU - Cantarini, Luca
AU - Galeazzi, Mauro
AU - Ruscitti, Piero
AU - Giacomelli, Roberto
AU - Caso, Francesco
AU - Galozzi, Paola
AU - Punzi, Leonardo
PY - 2016
Y1 - 2016
N2 - Adult-onset Still’s disease (AOSD) is a systemic inflammatory condition of unknown aetiology characterized by typical episodes of spiking fever, evanescent rash, arthralgia, leukocytosis and hyperferritinemia. Given the lack of data in Italian series, we promote a multicentric data collection to characterize the clinical phenotype of Italian patients with AOSD. Data from 245 subjects diagnosed with AOSD were collected by 15 centres between March and May 2013. The diagnosis was made following Yamaguchi’s criteria. Data regarding clinical manifestations, laboratory features, disease course and treatments were reported and compared with those presented in other published series of different ethnicity. The most frequent features were the following: arthritis (93 %), pyrexia (92.6 %), leukocytosis (89 %), negative ANA (90.4 %) and neutrophilia (82 %). As compared to other North American, North European, Middle Eastern and Far Eastern cohorts, Italian data show differences in clinical and laboratory findings. Regarding the treatments, in 21.9 % of cases, corticosteroids and traditional DMARDs have not been able to control the disease while biologics have been shown to be effective in 48 to 58 patients. This retrospective work summarizes the largest Italian multicentre series of AOSD patients and presents clinical and laboratory features that appear to be influenced by the ethnicity of the affected subjects.
AB - Adult-onset Still’s disease (AOSD) is a systemic inflammatory condition of unknown aetiology characterized by typical episodes of spiking fever, evanescent rash, arthralgia, leukocytosis and hyperferritinemia. Given the lack of data in Italian series, we promote a multicentric data collection to characterize the clinical phenotype of Italian patients with AOSD. Data from 245 subjects diagnosed with AOSD were collected by 15 centres between March and May 2013. The diagnosis was made following Yamaguchi’s criteria. Data regarding clinical manifestations, laboratory features, disease course and treatments were reported and compared with those presented in other published series of different ethnicity. The most frequent features were the following: arthritis (93 %), pyrexia (92.6 %), leukocytosis (89 %), negative ANA (90.4 %) and neutrophilia (82 %). As compared to other North American, North European, Middle Eastern and Far Eastern cohorts, Italian data show differences in clinical and laboratory findings. Regarding the treatments, in 21.9 % of cases, corticosteroids and traditional DMARDs have not been able to control the disease while biologics have been shown to be effective in 48 to 58 patients. This retrospective work summarizes the largest Italian multicentre series of AOSD patients and presents clinical and laboratory features that appear to be influenced by the ethnicity of the affected subjects.
KW - Adult-onset Still’s disease
KW - Biologic drugs
KW - Clinical presentation
KW - Laboratory findings
KW - Retrospective study
KW - Rheumatology
KW - Adult-onset Still’s disease
KW - Biologic drugs
KW - Clinical presentation
KW - Laboratory findings
KW - Retrospective study
KW - Rheumatology
UR - http://hdl.handle.net/10807/94039
U2 - 10.1007/s10067-016-3308-8
DO - 10.1007/s10067-016-3308-8
M3 - Article
SN - 0770-3198
VL - 35
SP - 1683
EP - 1689
JO - Clinical Rheumatology
JF - Clinical Rheumatology
ER -