TY - JOUR
T1 - Adult height and risk of gastric cancer: a pooled analysis within the Stomach cancer Pooling Project
AU - Giraldi, Luca
AU - Stojanovic, Jovana
AU - Arzani, Dario
AU - Persiani, Roberto
AU - Hu, Jinfu
AU - Johnson, Kenneth C
AU - Zhang, Zuo-Feng
AU - Ferraroni, Monica
AU - Palli, Domenico
AU - Yu, Guo-Pei
AU - La Vecchia, Carlo
AU - Pelucchi, Claudio
AU - Lunet, Nuno
AU - Ferro, Ana
AU - Malekzadeh, Reza
AU - Muscat, Joshua
AU - Zaridze, David
AU - Maximovich, Dmitry
AU - Aragones, Nuria
AU - Martin, Vicente
AU - Vioque, Jesùs
AU - Navarrete-Munoz, Eva M
AU - Pakseresht, Mohammadreza
AU - Negri, Eva
AU - Rota, Matteo
AU - Pourfarzi, Farhad
AU - Mu, Lina
AU - Kurtz, Robert C
AU - Lagiou, Areti
AU - Lagiou, Pagona
AU - Pastorino, Roberta
AU - Boccia, Stefania
PY - 2020
Y1 - 2020
N2 - Background: The association between height and risk of gastric cancer has been studied in several epidemiological studies with contrasting results. The aim of this study is to examine the association between adult height and gastric cancer within a large pooled analysis of case-control studies members of the Stomach cancer Pooling (StoP) Project consortium.\r\n\r\nMethods: Data from 18 studies members of the StoP consortium were collected and analyzed. A multivariable logistic regression model was used to estimate the study-specific odds ratios (ORs) and 95% confidence intervals (CIs) for the association between 10-cm increase in height and risk of gastric cancer. Age, sex, tobacco smoking, alcohol consumption, social class, geographical area and Helicobacter pylori (H. pylori) status were included in the regression model. Resulting estimates were then pooled with random-effect model. Analyses were conducted overall and in strata of selected variables.\r\n\r\nResults: A total of 7562 cases and 19 033 controls were included in the analysis. The pooled OR was 0.96 (95% CI 0.87-1.05). A sensitivity analysis was performed restricting the results to the studies with information on H. pylori status, resulting in an OR of 0.97 (95% CI 0.79-1.20).\r\n\r\nConclusion: Our study does not support a strong and consistent association between adult height and gastric cancer.
AB - Background: The association between height and risk of gastric cancer has been studied in several epidemiological studies with contrasting results. The aim of this study is to examine the association between adult height and gastric cancer within a large pooled analysis of case-control studies members of the Stomach cancer Pooling (StoP) Project consortium.\r\n\r\nMethods: Data from 18 studies members of the StoP consortium were collected and analyzed. A multivariable logistic regression model was used to estimate the study-specific odds ratios (ORs) and 95% confidence intervals (CIs) for the association between 10-cm increase in height and risk of gastric cancer. Age, sex, tobacco smoking, alcohol consumption, social class, geographical area and Helicobacter pylori (H. pylori) status were included in the regression model. Resulting estimates were then pooled with random-effect model. Analyses were conducted overall and in strata of selected variables.\r\n\r\nResults: A total of 7562 cases and 19 033 controls were included in the analysis. The pooled OR was 0.96 (95% CI 0.87-1.05). A sensitivity analysis was performed restricting the results to the studies with information on H. pylori status, resulting in an OR of 0.97 (95% CI 0.79-1.20).\r\n\r\nConclusion: Our study does not support a strong and consistent association between adult height and gastric cancer.
KW - adult height
KW - gastric cancer
KW - adult height
KW - gastric cancer
UR - https://publicatt.unicatt.it/handle/10807/186820
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85151574711&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85151574711&origin=inward
U2 - 10.1097/CEJ.0000000000000613
DO - 10.1097/CEJ.0000000000000613
M3 - Article
SN - 0959-8278
VL - Publish Ahead of Print
SP - 1
EP - 7
JO - European Journal of Cancer Prevention
JF - European Journal of Cancer Prevention
IS - settembre
ER -
