TY - JOUR
T1 - Adrenal disorders: Is there Any role for vitamin D?
AU - Tirabassi, G
AU - Salvio, G
AU - Altieri, B
AU - Ronchi, CL
AU - Della Casa, S
AU - Pontecorvi, Alfredo
AU - Balercia, G
PY - 2017
Y1 - 2017
N2 - An emerging branch of research is examining the linkage between Vitamin D and nonskeletal disorders, including endocrine diseases. In this regard, a still little studied aspect concerns the involvement of vitamin D in adrenal gland disorders. Adrenal gland disorders, which might be theoretically affected by vitamin D unbalance, include adrenal insufficiency, Cushing's syndrome, adrenocortical tumors and hyperaldosteronism. In this review, we provide an updated document, which tries to collect and discuss the limited evidence to be found in the literature about the relationship between vitamin D and adrenal disorders. We conclude that there is insufficient evidence proving a causal relationship between vitamin D levels and adrenal disorders. Evidence coming from cross-sectional clinical studies can hardly clarify what comes first between vitamin D unbalance and adrenal disease. On the other hand, longitudinal studies monitoring the levels of vitamin D in patients with adrenal disorders or, conversely, the possible development of adrenal pathologies in subjects affected by impaired vitamin D levels would be able to elucidate this still unclear issue.
AB - An emerging branch of research is examining the linkage between Vitamin D and nonskeletal disorders, including endocrine diseases. In this regard, a still little studied aspect concerns the involvement of vitamin D in adrenal gland disorders. Adrenal gland disorders, which might be theoretically affected by vitamin D unbalance, include adrenal insufficiency, Cushing's syndrome, adrenocortical tumors and hyperaldosteronism. In this review, we provide an updated document, which tries to collect and discuss the limited evidence to be found in the literature about the relationship between vitamin D and adrenal disorders. We conclude that there is insufficient evidence proving a causal relationship between vitamin D levels and adrenal disorders. Evidence coming from cross-sectional clinical studies can hardly clarify what comes first between vitamin D unbalance and adrenal disease. On the other hand, longitudinal studies monitoring the levels of vitamin D in patients with adrenal disorders or, conversely, the possible development of adrenal pathologies in subjects affected by impaired vitamin D levels would be able to elucidate this still unclear issue.
KW - Adrenal gland disorders
KW - Adrenal insufficiency
KW - Adrenal tumors
KW - Cushing's syndrome
KW - Hyperaldosteronism
KW - Vitamin D
KW - Adrenal gland disorders
KW - Adrenal insufficiency
KW - Adrenal tumors
KW - Cushing's syndrome
KW - Hyperaldosteronism
KW - Vitamin D
UR - https://publicatt.unicatt.it/handle/10807/171734
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84991755553&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84991755553&origin=inward
U2 - 10.1007/s11154-016-9391-y
DO - 10.1007/s11154-016-9391-y
M3 - Article
SN - 1389-9155
VL - 18
SP - 355
EP - 362
JO - Reviews in Endocrine and Metabolic Disorders
JF - Reviews in Endocrine and Metabolic Disorders
IS - 3
ER -