Adjuvant chemotherapy does not improve disease-free survival in FIGO stage IC ovarian granulosa cell tumors: The MITO-9 study

G. Mangili, J. Ottolina, G. Cormio, Vera Loizzi, P. De Iaco, D. A. Pellegrini, M. Candiani, G. Giorda, G. Scarfone, S. C. Cecere, L. Frigerio, A. Gadducci, Claudia Marchetti, Maria Gabriella Ferrandina

Risultato della ricerca: Contributo in rivistaArticolo in rivista

21 Citazioni (Scopus)


Objective Evidence-based management of granulosa cell tumors of the ovary (GCT) has been not yet standardized: surgery, including fertility-sparing procedures for young women, has been traditionally the standard treatment; on the other hand, chemotherapy has been used for treatment of advanced and/or recurrent disease. However, very limited experience, has been selectively focused on the role of adjuvant chemotherapy in stage IC patients. The objective of this retrospective study was to assess the efficacy of first line postoperative chemotherapy in patients with stage IC treated at the Italian Centers involved in the MITO (Multicenter Italian Trials in Ovarian cancer) Group. Patients and methods A retrospective multi-institutional review of patients with GCT of the ovary at FIGO stage IC treated or referred to MITO centers was conducted. Surgical outcome, pathological findings and follow-up data were analysed. Kaplan–Meier and Cox proportional hazards analyses were used to determine the predictors factors for disease free survival. Results A total of 40 patients with primary GCT of the ovary at FIGO stage IC were identified. The median follow-up period was 96 months (range 7–300). At multivariate analysis, surgical treatment outside MITO centers and incomplete surgical staging were independent poor prognostic indicators for recurrence; adjuvant chemotherapy did not retain significant predictive value for recurrence. Conclusions This study raises the question about the value of adjuvant chemotherapy in stage IC GCT: a comprehensive evaluation of a larger series is urgently needed in order to characterize stage IC substages who can be spared treatment toxicity.
Lingua originaleEnglish
pagine (da-a)276-280
Numero di pagine5
RivistaGynecologic Oncology
Stato di pubblicazionePubblicato - 2016


  • Adjuvant chemotherapy
  • Adult
  • Aged
  • Chemotherapy, Adjuvant
  • Disease-Free Survival
  • Female
  • Granulosa Cell Tumor
  • Granulosa cell tumors of the ovary
  • Humans
  • MITO
  • Middle Aged
  • Neoplasm Staging
  • Obstetrics and Gynecology
  • Oncology
  • Prognostic factors
  • Relapse
  • Retrospective Studies
  • Stage IC


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