Abstract
Adipose tissue represents a hot topic in regenerative medicine because of the tissue source abundance, the relatively easy retrieval,
and the inherent biological properties of mesenchymal stem cells residing in its stroma. Adipose-derived mesenchymal stem
cells (ASCs) are indeed multipotent somatic stem cells exhibiting growth kinetics and plasticity, proved to induce efficient tissue
regeneration in several biomedical applications. A defined consensus for their isolation, classification, and characterization has
been very recently achieved. In particular, bone tissue reconstruction and regeneration based on ASCs has emerged as a promising
approach to restore structure and function of bone compromised by injury or disease. ASCs have been used in combination with
osteoinductive biomaterial and/or osteogenic molecules, in either static or dynamic culture systems, to improve bone regeneration
in several animal models. To date, few clinical trials on ASC-based bone reconstruction have been concluded and proved effective.
The aim of this review is to dissect the state of the art on ASC use in bone regenerative applications in the attempt to provide a
comprehensive coverage of the topics, from the basic laboratory to recent clinical applications.
Lingua originale | English |
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pagine (da-a) | 1-11 |
Numero di pagine | 11 |
Rivista | BioMed Research International |
Volume | 2013 |
DOI | |
Stato di pubblicazione | Pubblicato - 2013 |
Keywords
- Adipose tissue
- Mesenchymal Cells
- bone regeneration