Adipose and muscle tissue profile of CD36 transcripts in obese subjects highlights the role of CD36 in fatty acid homeostasis and insulin resistance

Caterina Conte, Terri A. Pietka, Timothy Schappe, Elisa Fabbrini, Bruce W. Patterson, Samuel Klein, Nada A. Abumrad, Latisha Love-Gregory

Risultato della ricerca: Contributo in rivistaArticolo in rivista

13 Citazioni (Scopus)

Abstract

Fatty acid (FA) metabolism is tightly regulated across several tissues and impacts insulin sensitivity. CD36 facilitates cellular FA uptake, and CD36 genetic variants associate with lipid abnormalities and susceptibility to metabolic syndrome. The objective of this study was to gain insight regarding the in vivo metabolic influence of muscle and adipose tissue CD36. For this, we determined the relationships between CD36 alternative transcripts, which can reflect tissue-specific CD36 regulation, and measures of FA metabolism and insulin resistance.
Lingua originaleEnglish
pagine (da-a)1990-1997
Numero di pagine8
RivistaDiabetes Care
Volume37
DOI
Stato di pubblicazionePubblicato - 2014
Pubblicato esternamente

Keywords

  • adipose tissue
  • cd36

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