Adipocytes and neutrophils give a helping hand to pancreatic cancers

Vincenzo Bronte; Giampaolo Tortora

doi:10.1158/2159-8290.CD-16-0682

Adipocytes and neutrophils give a helping hand to pancreatic cancers

Vincenzo Bronte, Giampaolo Tortora

Ospedale Policlinico

Risultato della ricerca: Contributo in rivista › Articolo

3 Citazioni (Scopus)

Abstract

Obesity-induced inflammation can build up a confined microenvironment in pancreatic adenocarcinoma that is associated with increased desmoplasia, neutrophil recruitment, reduced delivery of chemotherapeutic drugs, and immune evasion. Targeting molecular pathways empowering this circuit might represent a necessary measure to reach clinical efficacy for combination therapies in patients with excess body weight.

Lingua originale	Inglese
pagine (da-a)	821-823
Numero di pagine	3
Rivista	Cancer Discovery
Volume	6
DOI	https://doi.org/10.1158/2159-8290.CD-16-0682
Stato di pubblicazione	Pubblicato - 2016

Keywords

Adipocytes
Animals
Cell Communication
Cytokines
Humans
Inflammation Mediators
Neoplastic Stem Cells
Neutrophils
Oncology
Pancreatic Neoplasms
Tumor Microenvironment

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title = "Adipocytes and neutrophils give a helping hand to pancreatic cancers",

abstract = "Obesity-induced inflammation can build up a confined microenvironment in pancreatic adenocarcinoma that is associated with increased desmoplasia, neutrophil recruitment, reduced delivery of chemotherapeutic drugs, and immune evasion. Targeting molecular pathways empowering this circuit might represent a necessary measure to reach clinical efficacy for combination therapies in patients with excess body weight.",

keywords = "Adipocytes, Animals, Cell Communication, Cytokines, Humans, Inflammation Mediators, Neoplastic Stem Cells, Neutrophils, Oncology, Pancreatic Neoplasms, Tumor Microenvironment, Adipocytes, Animals, Cell Communication, Cytokines, Humans, Inflammation Mediators, Neoplastic Stem Cells, Neutrophils, Oncology, Pancreatic Neoplasms, Tumor Microenvironment",

author = "Vincenzo Bronte and Giampaolo Tortora",

year = "2016",

doi = "10.1158/2159-8290.CD-16-0682",

language = "English",

volume = "6",

pages = "821--823",

journal = "Cancer Discovery",

issn = "2159-8274",

publisher = "American Association for Cancer Research Inc.",

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T1 - Adipocytes and neutrophils give a helping hand to pancreatic cancers

AU - Bronte, Vincenzo

AU - Tortora, Giampaolo

PY - 2016

Y1 - 2016

N2 - Obesity-induced inflammation can build up a confined microenvironment in pancreatic adenocarcinoma that is associated with increased desmoplasia, neutrophil recruitment, reduced delivery of chemotherapeutic drugs, and immune evasion. Targeting molecular pathways empowering this circuit might represent a necessary measure to reach clinical efficacy for combination therapies in patients with excess body weight.

AB - Obesity-induced inflammation can build up a confined microenvironment in pancreatic adenocarcinoma that is associated with increased desmoplasia, neutrophil recruitment, reduced delivery of chemotherapeutic drugs, and immune evasion. Targeting molecular pathways empowering this circuit might represent a necessary measure to reach clinical efficacy for combination therapies in patients with excess body weight.

KW - Adipocytes

KW - Animals

KW - Cell Communication

KW - Cytokines

KW - Humans

KW - Inflammation Mediators

KW - Neoplastic Stem Cells

KW - Neutrophils

KW - Oncology

KW - Pancreatic Neoplasms

KW - Tumor Microenvironment

KW - Adipocytes

KW - Animals

KW - Cell Communication

KW - Cytokines

KW - Humans

KW - Inflammation Mediators

KW - Neoplastic Stem Cells

KW - Neutrophils

KW - Oncology

KW - Pancreatic Neoplasms

KW - Tumor Microenvironment

UR - http://hdl.handle.net/10807/134265

UR - http://cancerdiscovery.aacrjournals.org/content/6/8/821.full.pdf

U2 - 10.1158/2159-8290.CD-16-0682

DO - 10.1158/2159-8290.CD-16-0682

M3 - Article

SN - 2159-8274

VL - 6

SP - 821

EP - 823

JO - Cancer Discovery

JF - Cancer Discovery

ER -

Adipocytes and neutrophils give a helping hand to pancreatic cancers

Abstract

Keywords

OSS delle Nazioni Unite

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