Adipocytes and neutrophils give a helping hand to pancreatic cancers

Vincenzo Bronte; Giampaolo Tortora

doi:10.1158/2159-8290.CD-16-0682

Adipocytes and neutrophils give a helping hand to pancreatic cancers

Vincenzo Bronte, Giampaolo Tortora

Ospedale Policlinico

Risultato della ricerca: Contributo in rivista › Articolo in rivista

3 Citazioni (Scopus)

Abstract

Obesity-induced inflammation can build up a confined microenvironment in pancreatic adenocarcinoma that is associated with increased desmoplasia, neutrophil recruitment, reduced delivery of chemotherapeutic drugs, and immune evasion. Targeting molecular pathways empowering this circuit might represent a necessary measure to reach clinical efficacy for combination therapies in patients with excess body weight.

Lingua originale	English
pagine (da-a)	821-823
Numero di pagine	3
Rivista	Cancer Discovery
Volume	6
DOI	https://doi.org/10.1158/2159-8290.CD-16-0682
Stato di pubblicazione	Pubblicato - 2016

Keywords

Adipocytes
Animals
Cell Communication
Cytokines
Humans
Inflammation Mediators
Neoplastic Stem Cells
Neutrophils
Oncology
Pancreatic Neoplasms
Tumor Microenvironment

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title = "Adipocytes and neutrophils give a helping hand to pancreatic cancers",

abstract = "Obesity-induced inflammation can build up a confined microenvironment in pancreatic adenocarcinoma that is associated with increased desmoplasia, neutrophil recruitment, reduced delivery of chemotherapeutic drugs, and immune evasion. Targeting molecular pathways empowering this circuit might represent a necessary measure to reach clinical efficacy for combination therapies in patients with excess body weight.",

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author = "Vincenzo Bronte and Giampaolo Tortora",

year = "2016",

doi = "10.1158/2159-8290.CD-16-0682",

language = "English",

volume = "6",

pages = "821--823",

journal = "Cancer Discovery",

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publisher = "American Association for Cancer Research",

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T1 - Adipocytes and neutrophils give a helping hand to pancreatic cancers

AU - Bronte, Vincenzo

AU - Tortora, Giampaolo

PY - 2016

Y1 - 2016

N2 - Obesity-induced inflammation can build up a confined microenvironment in pancreatic adenocarcinoma that is associated with increased desmoplasia, neutrophil recruitment, reduced delivery of chemotherapeutic drugs, and immune evasion. Targeting molecular pathways empowering this circuit might represent a necessary measure to reach clinical efficacy for combination therapies in patients with excess body weight.

AB - Obesity-induced inflammation can build up a confined microenvironment in pancreatic adenocarcinoma that is associated with increased desmoplasia, neutrophil recruitment, reduced delivery of chemotherapeutic drugs, and immune evasion. Targeting molecular pathways empowering this circuit might represent a necessary measure to reach clinical efficacy for combination therapies in patients with excess body weight.

KW - Adipocytes

KW - Animals

KW - Cell Communication

KW - Cytokines

KW - Humans

KW - Inflammation Mediators

KW - Neoplastic Stem Cells

KW - Neutrophils

KW - Oncology

KW - Pancreatic Neoplasms

KW - Tumor Microenvironment

KW - Adipocytes

KW - Animals

KW - Cell Communication

KW - Cytokines

KW - Humans

KW - Inflammation Mediators

KW - Neoplastic Stem Cells

KW - Neutrophils

KW - Oncology

KW - Pancreatic Neoplasms

KW - Tumor Microenvironment

UR - http://hdl.handle.net/10807/134265

UR - http://cancerdiscovery.aacrjournals.org/content/6/8/821.full.pdf

U2 - 10.1158/2159-8290.CD-16-0682

DO - 10.1158/2159-8290.CD-16-0682

M3 - Article

SN - 2159-8274

VL - 6

SP - 821

EP - 823

JO - Cancer Discovery

JF - Cancer Discovery

ER -

Adipocytes and neutrophils give a helping hand to pancreatic cancers

Abstract

Keywords

OSS delle Nazioni Unite

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