Adipocytes and neutrophils give a helping hand to pancreatic cancers

Giampaolo Tortora, Vincenzo Bronte

Risultato della ricerca: Contributo in rivistaArticolo in rivista

2 Citazioni (Scopus)

Abstract

Obesity-induced inflammation can build up a confined microenvironment in pancreatic adenocarcinoma that is associated with increased desmoplasia, neutrophil recruitment, reduced delivery of chemotherapeutic drugs, and immune evasion. Targeting molecular pathways empowering this circuit might represent a necessary measure to reach clinical efficacy for combination therapies in patients with excess body weight.
Lingua originaleEnglish
pagine (da-a)821-823
Numero di pagine3
RivistaCancer Discovery
Volume6
DOI
Stato di pubblicazionePubblicato - 2016

Keywords

  • Adipocytes
  • Animals
  • Cell Communication
  • Cytokines
  • Humans
  • Inflammation Mediators
  • Neoplastic Stem Cells
  • Neutrophils
  • Oncology
  • Pancreatic Neoplasms
  • Tumor Microenvironment

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