Adherence and plasma drug concentrations are predictors of confirmed virologic response after 24-week salvage highly active antiretroviral therapy

Simona Di Giambenedetto, E Quiros Roldan, C Torti, G Lapadula, N Ladisa, V Micheli, A Patroni, M Cusato, P Pierotti, V Tirelli, Mc Uccelli, F Castelnuovo, F Gargiulo, N Manca, G. Carosi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

5 Citazioni (Scopus)

Abstract

Data from 197 patients for whom highly active antiretroviral therapy (HAART) failed, who started a new regimen chosen under the guide of resistance testing results interpreted by experts, were retrospectively studied, provided that at least 2 determinations of adherence and plasma drug concentrations were performed during the follow-up. Univariate and multivariable logistic regression analyses were conducted, using confirmed virologic response at week 24 as outcome measure (i.e., achievement of undetectable HIV plasma viral load at any time point before week 24 and its maintenance up to week 24). Suboptimal drug concentrations (odds ratio [OR]: 0.3; 95% confidence interval [CI] 0.2-0.7; p = 0.006) and suboptimal adherence (OR: 0.4; 95% CI 0.2-0.8; p = 0.014) were both negative independent predictors of sustained virologic response, while the use of boosted protease inhibitor-containing regimens resulted to be protective (OR: 2.4; 95% CI 1.1-5.3; p = 0.032).
Lingua originaleEnglish
pagine (da-a)92-99
Numero di pagine8
RivistaAIDS Patient Care and STDs
Stato di pubblicazionePubblicato - 2007

Keywords

  • Aderenza
  • TDM

Fingerprint

Entra nei temi di ricerca di 'Adherence and plasma drug concentrations are predictors of confirmed virologic response after 24-week salvage highly active antiretroviral therapy'. Insieme formano una fingerprint unica.

Cita questo