Adaptive immunity, inflammation, and cardiovascular complications in type 1 and type 2 diabetes mellitus

Giovanna Liuzzo, Dario Pitocco, Filippo Crea, Daniela Pedicino, Francesco Trotta, Ada Francesca Giglio, Simona Giubilato, Francesca Martini, Francesco Zaccardi, Giuseppe Scavone, Pio Cialdella, Maria Teresa Cardillo, Giovanni Ghirlanda

Risultato della ricerca: Contributo in rivistaArticolo in rivista

35 Citazioni (Scopus)

Abstract

Diabetes mellitus (DM) is a pandemics that affects more than 170 million people worldwide, associated with increased mortality and morbidity due to coronary artery disease (CAD). In type 1 (T1) DM, the main pathogenic mechanism seems to be the destruction of pancreatic β -cells mediated by autoreactive T-cells resulting in chronic insulitis, while in type 2 (T2) DM primary insulin resistance, rather than defective insulin production due to β -cell destruction, seems to be the triggering alteration. In our study, we investigated the role of systemic inflammation and T-cell subsets in T1- and T2DM and the possible mechanisms underlying the increased cardiovascular risk associated with these diseases.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaJournal of Diabetes Research
Volume2013
DOI
Stato di pubblicazionePubblicato - 2013

Keywords

  • Adaptive Immunity
  • Adult
  • Aged
  • Cardiovascular Diseases
  • Cell Line
  • Diabetes Mellitus, Type 1
  • Diabetes Mellitus, Type 2
  • Female
  • Humans
  • Inflammation
  • Insulin Resistance
  • Insulin-Secreting Cells
  • Male
  • Middle Aged
  • T-Lymphocyte Subsets

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