Acute Ibuprofen Intoxication: report on a case and review of the literature

Fabio De Giorgio, Riccardo Rossi, Maria Lodise, Nadia Fucci

Risultato della ricerca: Contributo in rivistaArticolo in rivista

7 Citazioni (Scopus)


A fatality following the ingestion of ibupofen is reported. Ibuprofen is a prototypical nonsteroidal anti-inflammatory drug (NSAID) widely prescribed as an analgesic, anti-inflammatory and anti-pyretic agent. To date, there are few case reports of fatal overdose with ibuprofen, following ibuprofen self-poisoning or accidental overdose. Here we report the case of a 51-year-old man with medical history of psychiatric disease, who was brought to the ED by ambulance with a chief complaint of having taken large amounts of drugs in a suicide attempt. Multiple empty containers of medications (ibuprofen, meloxicam, celecoxib, risperidon, citalopram, ketorolac, bromazepam) were found at the scene. He died 4 hours after admission to the ED, despite vigorous supportive care. Toxicological analyses were performed using a gas chromatography-mass spectrometry (GC/MS) technique. The estimated ibuprofen concentration in plasma was 600 mcg/ml; gastric content were 200 mcg/ml for this compound. Our report describes results of the forensic investigation and discuss the review of the literature.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
Stato di pubblicazionePubblicato - 2012


  • ibuprofen
  • nonsteroidal anti-inflammatory drug


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