Activity of caffeic acid derivatives against Candida albicans biofilm

Franco Pandolfi, Daniela De Vita, Laura Friggeri, Felicia Diodata D'Auria, Fabiana Pandolfi, Francesco Piccoli, Simona Panella, Anna Teresa Palamara, Giovanna Simonetti, Luigi Scipione, Roberto Di Santo, Roberta Costi, Silvano Tortorella

Risultato della ricerca: Contributo in rivistaArticolo in rivista

37 Citazioni (Scopus)

Abstract

The aim of this study was to evaluate the caffeic acid (1) and ester derivatives (2-10) against Candida albicans biofilm and to investigate whether these compounds are able to inhibit the biofilm formation or destroy pre-formed biofilm. Caffeic acid ester 7, cinnamic acid ester 8 and 3,4-dihydroxybenzoic acid ester 10 are more active than fluconazole, used as reference drug, both on biofilm in formation with MIC50 values of 32, 32 and 16μg/mL, respectively, and in the early stage of biofilm formation (4h) with MIC50 values of 64, 32 and 64μg/mL, respectively. These esters result also more active than fluconazole on mature biofilm (24h), especially 8 and 10 with MIC50 values of 64μg/mL.
Lingua originaleEnglish
pagine (da-a)1502-1505
Numero di pagine4
RivistaBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume24
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • Anti-biofilm agents
  • Antifungal Agents
  • Biofilm formation
  • Biofilms
  • Caffeic Acids
  • Caffeic acid
  • Candida albicans
  • Candida albicans biofilm
  • Cell Line, Tumor
  • Cell Survival
  • Humans
  • Microbial Sensitivity Tests

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