Acquisition of FKS2 mutation after echinocandin treatment of infective endocarditis by Candida glabrata

Maurizio Sanguinetti, Silvia Corcione, Antonio D’Avolio, Daniela Pasero, Alice Trentalange, Nicole Pagani, Francesco Giuseppe De Rosa

Risultato della ricerca: Contributo in rivistaArticolo in rivista

1 Citazioni (Scopus)

Abstract

Bloodstream infections caused by non-albicans Candida species are increasing and echinocandins have been extensively used especially in patients with hemodynamic instability, previous antifungal treatment, and hospital risk factors for intrinsic or acquired resistance to azoles. Candida glabrata resistance to echinocandins is reported and is generally associated with previous use of echinocandins; FKS gene mutations have been associated with a worse outcome. We report the case of a 65-year-old woman who developed candidemia and endocarditis by C. glabrata with a newly acquired FKS mutation 24 months after successful treatment of infective endocarditis by C. glabrata with a double dosage of anidulafungin (200 mg daily) followed by oral voriconazole. Driven by high echinocandin MICs the strain taken by intraoperative cultures was further analyzed in a referral microbiology laboratory, confirming the new onset of point mutation S633P of the FKS2 gene.
Lingua originaleEnglish
pagine (da-a)328-331
Numero di pagine4
RivistaLE INFEZIONI IN MEDICINA
Volume27
Stato di pubblicazionePubblicato - 2019

Keywords

  • C
  • Echinocandins
  • FKS
  • Fungal endocarditis
  • Glabrata
  • MIC

Fingerprint Entra nei temi di ricerca di 'Acquisition of FKS2 mutation after echinocandin treatment of infective endocarditis by Candida glabrata'. Insieme formano una fingerprint unica.

Cita questo