[Acidosis is associated with an intracellular accumulation of Ca2+. Its role in the modulation of myocardial contractility]

Giovanni Gambassi, Mc Capogrossi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Myocardial acidosis, as during ischemia, profoundly modifies excitation-contraction mechanisms. The decreased myofilament sensitivity to Ca2+ reduces contractility regardless of an intracellular accumulation of Ca2+. To determine the source for this increase in Ca2+ we evaluated the effect of acidosis on diastolic [Ca2+] and mitochondrial [Ca2+]. We used single cardiac cells loaded with the fluorescent probes, indo-1 for Ca2+ and SNARF-1 for pH. Acidosis increases [Ca2+] both in cytosol and mitochondria. The cytosolic accumulation depends, most likely, on an active release from mitochondria. A competition among Ca2+ and H+ ions may, instead, explains the increase in mitochondrial [Ca2+].
Titolo tradotto del contributo[Autom. eng. transl.] [Acidosis is associated with an intracellular accumulation of Ca2+. Its role in the modulation of myocardial contractility]
Lingua originaleItalian
pagine (da-a)587-589
Numero di pagine3
RivistaCardiologia
Volume37
Stato di pubblicazionePubblicato - 1992

Keywords

  • Acidosis
  • Animals
  • Benzopyrans
  • Calcium
  • Cardiomyopathies
  • Fluorescence
  • Fluorescent Dyes
  • Hydrogen-Ion Concentration
  • Indoles
  • Mitochondria, Heart
  • Myocardial Contraction
  • Rats

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