Achalasia: current treatment options

Pietro Familiari, Guido Costamagna, Santi Greco, Giovanni Gigante, Ivo Boskoski, Ance Volkanovska

Risultato della ricerca: Contributo in rivistaArticolo in rivista

7 Citazioni (Scopus)

Abstract

Achalasia is a rare esophageal motility disorder, characterized by impaired swallow-induced, lower esophageal sphincter (LES) relaxation and defective esophageal peristalsis. Unfortunately, there are no etiological therapies for achalasia. Patients present with dysphagia, chest pain and regurgitation of undigested food, often leading to weight loss. The currently available treatments have the common aim of relieving symptoms by decreasing the pressure of the LES. This can be achieved with some medications, by inhibiting the cholinergic innervation (botulinum toxin), by stretching (endoscopic dilation) or cutting (surgery) the LES. Recently, other therapeutic options, including per-oral endoscopic myotomy have been developed and are gaining international consensus. The authors report on the benefits and weaknesses of the different therapies and provide an updated approach to the management of achalasia.
Lingua originaleEnglish
pagine (da-a)1101-1114
Numero di pagine14
RivistaEXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
Volume9
DOI
Stato di pubblicazionePubblicato - 2015

Keywords

  • POEM esophageal motility disorders
  • achalasia
  • botulinum toxin injection
  • dysphagia
  • esophageal manometry
  • esophageal myotomy
  • high-resolution manometry
  • pneumatic balloon dilation
  • surgery

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