Accelerated cell-mediated broncho-obstructive reaction to inhaled stepronin: A case report

Antonino Romano; M. Di Fonso; Flaminio Mormile; D. Quaratino; F. Giuffreda; A. Venuti

doi:10.1111/j.1398-9995.1996.tb04605.x

Accelerated cell-mediated broncho-obstructive reaction to inhaled stepronin: A case report

Antonino Romano, M. Di Fonso, Flaminio Mormile, D. Quaratino, F. Giuffreda, A. Venuti

Università Cattolica del Sacro Cuore

Risultato della ricerca: Contributo in rivista › Articolo

6 Citazioni (Scopus)

Abstract

We describe the case of a 20-year-old man who developed an obstructive bronchial reaction accompanied by a maculopapular facial rash 8 h after an aerosol treatment with the mucolytic drug stepronin. The results of intradermal and patch testing with stepronin, together with those of bronchial challenge and histologic findings in patch-tested skin, indicate that the patient's reaction involved an accelerated cell-mediated mechanism of hypersensitivity. Bronchial challenges with methacholine demonstrated a transient increase in nonspecific bronchial hyperreactivity.

Lingua originale	Inglese
pagine (da-a)	269-271
Numero di pagine	3
Rivista	ALLERGY
Volume	51
DOI	https://doi.org/10.1111/j.1398-9995.1996.tb04605.x
Stato di pubblicazione	Pubblicato - 1996

Keywords

broncho-obstructive reaction
delayed hypersensitivity
stepronin

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10.1111/j.1398-9995.1996.tb04605.x

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title = "Accelerated cell-mediated broncho-obstructive reaction to inhaled stepronin: A case report",

abstract = "We describe the case of a 20-year-old man who developed an obstructive bronchial reaction accompanied by a maculopapular facial rash 8 h after an aerosol treatment with the mucolytic drug stepronin. The results of intradermal and patch testing with stepronin, together with those of bronchial challenge and histologic findings in patch-tested skin, indicate that the patient's reaction involved an accelerated cell-mediated mechanism of hypersensitivity. Bronchial challenges with methacholine demonstrated a transient increase in nonspecific bronchial hyperreactivity.",

keywords = "broncho-obstructive reaction, delayed hypersensitivity, stepronin, broncho-obstructive reaction, delayed hypersensitivity, stepronin",

author = "Antonino Romano and \{Di Fonso\}, M. and Flaminio Mormile and D. Quaratino and F. Giuffreda and A. Venuti",

year = "1996",

doi = "10.1111/j.1398-9995.1996.tb04605.x",

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T1 - Accelerated cell-mediated broncho-obstructive reaction to inhaled stepronin: A case report

AU - Romano, Antonino

AU - Di Fonso, M.

AU - Mormile, Flaminio

AU - Quaratino, D.

AU - Giuffreda, F.

AU - Venuti, A.

PY - 1996

Y1 - 1996

N2 - We describe the case of a 20-year-old man who developed an obstructive bronchial reaction accompanied by a maculopapular facial rash 8 h after an aerosol treatment with the mucolytic drug stepronin. The results of intradermal and patch testing with stepronin, together with those of bronchial challenge and histologic findings in patch-tested skin, indicate that the patient's reaction involved an accelerated cell-mediated mechanism of hypersensitivity. Bronchial challenges with methacholine demonstrated a transient increase in nonspecific bronchial hyperreactivity.

AB - We describe the case of a 20-year-old man who developed an obstructive bronchial reaction accompanied by a maculopapular facial rash 8 h after an aerosol treatment with the mucolytic drug stepronin. The results of intradermal and patch testing with stepronin, together with those of bronchial challenge and histologic findings in patch-tested skin, indicate that the patient's reaction involved an accelerated cell-mediated mechanism of hypersensitivity. Bronchial challenges with methacholine demonstrated a transient increase in nonspecific bronchial hyperreactivity.

KW - broncho-obstructive reaction

KW - delayed hypersensitivity

KW - stepronin

KW - broncho-obstructive reaction

KW - delayed hypersensitivity

KW - stepronin

UR - http://hdl.handle.net/10807/164524

U2 - 10.1111/j.1398-9995.1996.tb04605.x

DO - 10.1111/j.1398-9995.1996.tb04605.x

M3 - Article

SN - 0105-4538

VL - 51

SP - 269

EP - 271

JO - ALLERGY

JF - ALLERGY

ER -

Accelerated cell-mediated broncho-obstructive reaction to inhaled stepronin: A case report

Abstract

Keywords

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