A2A adenosine receptor antagonism enhances synaptic and motor effects of cocaine via CB1 cannabinoid receptor activation

Paolo Calabresi, Carmela Giampa', A Tozzi, A De Iure, V Marsili, R Romano, M Tantucci, M Di Filippo, C Costa, F Napolitano, Nb Mercuri, F Borsini, Fr Fusco, B Picconi, A Usiello

Risultato della ricerca: Contributo in rivistaArticolo in rivista

12 Citazioni (Scopus)

Abstract

Cocaine increases the level of endogenous dopamine (DA) in the striatum by blocking the DA transporter. Endogenous DA modulates glutamatergic inputs to striatal neurons and this modulation influences motor activity. Since D2 DA and A2A-adenosine receptors (A2A-Rs) have antagonistic effects on striatal neurons, drugs targeting adenosine receptors such as caffeine-like compounds, could enhance psychomotor stimulant effects of cocaine. In this study, we analyzed the electrophysiological effects of cocaine and A2A-Rs antagonists in striatal slices and the motor effects produced by this pharmacological modulation in rodents.
Lingua originaleEnglish
pagine (da-a)e38312-e38312
RivistaPLoS One
Volume7
DOI
Stato di pubblicazionePubblicato - 2012

Keywords

  • Adenosine receptor

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