TY - JOUR
T1 - A true isolated cognitive relapse in multiple sclerosis
AU - Pozzilli, Valeria
AU - Cruciani, Alessandro
AU - Capone, Fioravante
AU - Motolese, Francesco
AU - Rossi, Mariagrazia
AU - Pilato, Fabio
AU - Bianco, Assunta
AU - Mirabella, Massimiliano
AU - Giuffré, Guido Maria
AU - Calabria, Luigi Fausto
AU - Di Lazzaro, Vincenzo
PY - 2022
Y1 - 2022
N2 - Isolated cognitive relapses (ICRs) have been a matter of debate for the past few years. Currently, there is no clear consensus on such an entity, as cognitive decline usually accompanies typical multiple sclerosis (MS) relapses. Herein, we present the neuropsychological and neurophysiological manifestations of a patient who suddenly complained of confusion and memory loss, showing insight into her deficit, in absence of sensorimotor disturbances. Neuroimaging revealed a large tumefactive gadolinium-enhancing lesion localized in the left medial temporal lobe. The patient's symptoms persisted for months afterwards, despite corticosteroid treatment. We believe our patient experienced a true ICR. ICRs are rare entities in MS, but we should be alert to their existence in order to treat them promptly. Deepening their pathophysiology is equally important and neuropsychology combined with neurophysiology may be useful in this regard.
AB - Isolated cognitive relapses (ICRs) have been a matter of debate for the past few years. Currently, there is no clear consensus on such an entity, as cognitive decline usually accompanies typical multiple sclerosis (MS) relapses. Herein, we present the neuropsychological and neurophysiological manifestations of a patient who suddenly complained of confusion and memory loss, showing insight into her deficit, in absence of sensorimotor disturbances. Neuroimaging revealed a large tumefactive gadolinium-enhancing lesion localized in the left medial temporal lobe. The patient's symptoms persisted for months afterwards, despite corticosteroid treatment. We believe our patient experienced a true ICR. ICRs are rare entities in MS, but we should be alert to their existence in order to treat them promptly. Deepening their pathophysiology is equally important and neuropsychology combined with neurophysiology may be useful in this regard.
KW - Isolated cognitive relapse
KW - Memory loss
KW - Neurophysiology
KW - Neuropsychology
KW - Isolated cognitive relapse
KW - Memory loss
KW - Neurophysiology
KW - Neuropsychology
UR - http://hdl.handle.net/10807/222452
U2 - 10.1007/s10072-022-06441-w
DO - 10.1007/s10072-022-06441-w
M3 - Article
SN - 1590-1874
VL - 2022
SP - N/A-N/A
JO - Neurological Sciences
JF - Neurological Sciences
ER -