A "systems medicine" approach to the study of non-alcoholic fatty liver disease

Luca Miele, Antonio Grieco, Marcello Mancini, Loreta Kondili, Stefano Vella, Salvatore Petta, Luca Valenti, Elisabetta Bugianesi, Giovanni Targher, Stefano Bellentani, Ferruccio Bonino, Silvia Fargion, Ester Vanni, Ele Ferrannini, Carmela Loguercio, Amedeo Lonardo, Fabio Marra, Valerio Nobili, Gianluca Svegliati Baroni, Federico AlessandroStefano Ballestri, Maurizia Rossana Brunetto, Barbara Coco, Fabio Nascimbeni, Anna Prinster, Dante Romagnoli, Stefano Taddei

Risultato della ricerca: Contributo in rivistaArticolo in rivista

43 !!Citations (SciVal)

Abstract

The prevalence of fatty liver (steatosis) in the general population is rapidly increasing worldwide. The progress of knowledge in the physiopathology of fatty liver is based on the systems biology approach to studying the complex interactions among different physiological systems. Similarly, translational and clinical research should address the complex interplay between these systems impacting on fatty liver. The clinical needs drive the applications of systems medicine to re-define clinical phenotypes, assessing the multiple nature of disease susceptibility and progression (e.g. the definition of risk, prognosis, diagnosis criteria, and new endpoints of clinical trials). Based on this premise and in light of recent findings, the complex mechanisms involved in the pathology of fatty liver and their impact on the short- and long-term clinical outcomes of cardiovascular, metabolic liver diseases associated with steatosis are presented in this review using a new "systems medicine" approach. A new data set is proposed for studying the impairments of different physiological systems that have an impact on fatty liver in different subsets of subjects and patients.
Lingua originaleEnglish
pagine (da-a)333-342
Numero di pagine10
RivistaDIGESTIVE AND LIVER DISEASE
Volume48
DOI
Stato di pubblicazionePubblicato - 2016

Keywords

  • Disease Progression
  • Fatty liver
  • Gastroenterology
  • Hepatology
  • Humans
  • Medicine
  • Medicine (all)
  • NAFLD
  • NASH
  • Non-alcoholic Fatty Liver Disease
  • Personalized
  • Phenotype
  • Risk Factors
  • Systems Analysis
  • Systems Biology
  • Systems medicine

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