A systematic review of resectability and survival after concurrent chemoradiation in primarily unresectable pancreatic cancer.

Luigi Sofo, Giuseppina Sallustio, Francesco Deodato, Vincenzo Valentini, Alessio Giuseppe Morganti, Mariangela Massaccesi, Giuseppe La Torre, Luciana Caravatta, Rosa Tambaro, Marcello Ingrosso, Gabriella Macchia, Vincenzo Picardi, Edy Ippolito, Numa Cellini, A. Piscopo

Risultato della ricerca: Contributo in rivistaArticolo in rivista

120 Citazioni (Scopus)

Abstract

The objective of this study was to determine the effect on resection rate and survival of neoadjuvant chemoradiotherapy for primarily unresectable locally advanced pancreatic carcinoma. METHODS: A systematic review of recently published literature was performed. Resection rates and survival data were derived from reports published from 2000 onwards. Only recent studies, based on radiotherapy with standard dose and fractionation, have been analyzed. RESULTS: Thirteen studies with a total of 510 patients met selection criteria. A resection rate of 8.3-64.2% was reported (median, 26.5%). Of the operated patients, 57.1-100% (median, 87.5%) had R0 tumor resection. Most papers reported occasional pathological complete responses (CR, 3.0-8.8%). When outcome in all patients was considered, median survival ranged from 9 to 23 (median, 13.3) months, comparing favorably with literature data based on concurrent chemoradiation alone (range, 8.6-13 months). Surprisingly, in patients with unresectable tumor at presentation, median survival after surgery ranged from 16.4 to 32.3 (median, 23.6) months. CONCLUSIONS: The finding of a high proportion of R0 resection among all resections performed confirms the activity of neoadjuvant radiochemotherapy and should not be neglected. Based on these data, patients with unresectable pancreatic cancer without disease progression after chemoradiotherapy should be considered for radical surgery
Lingua originaleEnglish
pagine (da-a)194-205
Numero di pagine12
RivistaAnnals of Surgical Oncology
Volume17
Stato di pubblicazionePubblicato - 2010

Keywords

  • pancreatic cancer

Fingerprint

Entra nei temi di ricerca di 'A systematic review of resectability and survival after concurrent chemoradiation in primarily unresectable pancreatic cancer.'. Insieme formano una fingerprint unica.

Cita questo