A systematic quantitative morpho-volumetric analysis in infants with sagittal craniosynostosis and relationship with the severity of scaphocephalic deformity

Cesare Colosimo, Rosalinda Calandrelli, Fabio Pilato, Luca Massimi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Purpose: Among patients with isolated sagittal synostosis (ISS), the head shape varies considerably in relation to the severity of the abnormality. This study aimed to quantify skull base morphometry and intracranial volume to investigate their relationships with the severity of scaphocephaly. Methods: We studied 66 infants with ISS identifying three groups according to the morphological severity of cranial deformity (group I: mild deformity; group II: moderate deformity; group III: severe deformity), by combining two scaphocephaly severity indices as descriptors of the relation of three morphological measurements (length, width and height) We perform a quantitative analysis using high-resolution CT images calculating following parameters: cranial fossae dimensions, supratentorial (ICV) and infratentorial (PCFV) cranial volume, supratentorial (WBV) and infratentorial (PCFBV) brain volume, ICV/WBV, PCFV/PCFBV, supratentorial and infratentorial cerebrospinal fluid (CSF). Results: In all subgroups, anterior and middle skull base lengths were increased, while posterior hemifossae lengths were unchanged. In mild subgroup, ICV/WBV was significantly different and ICV, WBV and CSF supratentorial volume increased (p < 0.05). In moderate and severe subgroups, FCPV/FCPBV was significantly different and CSF infratentorial volume was reduced (p < 0.05); FCPBV was increased only in the severe subgroup (p < 0.05). Conclusion: This morpho-volumetric study provides new insights in understanding the compensatory changes occurring in infants at different stages of scaphocephaly severity. In particular, our study suggests that patients with severe deformity might have an earlier depletion of reserve mechanisms with a reduced compliance of the overall skull during encephalic growth and these patients might require early surgical cranial expansion.
Lingua originaleEnglish
pagine (da-a)585-594
Numero di pagine10
RivistaLA RADIOLOGIA MEDICA
Volume125
DOI
Stato di pubblicazionePubblicato - 2020

Keywords

  • Craniocephalic index
  • Craniosynostoses
  • Female
  • High-resolution CT
  • Humans
  • Imaging, Three-Dimensional
  • Infant
  • Male
  • Retrospective Studies
  • Sagittal craniosynostosis
  • Scaphocephaly
  • Severity of Illness Index
  • Skull Base
  • Tomography, X-Ray Computed
  • Vertico-longitudinal index

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