A small-molecule targeting the microRNA binding domain of argonaute 2 improves the retinoic acid differentiation response of the acute promyelocytic leukemia cell line NB4

Silvia Masciarelli, Roberto Quaranta, Ilaria Iosue, Gianni Colotti, Fabrizio Padula, Greta Varchi, Francesco Fazi, Alberto Del Rio

Risultato della ricerca: Contributo in rivistaArticolo in rivista

22 Citazioni (Scopus)

Abstract

Argonaute proteins are pivotal regulators of gene expression mediating miRNAs function. Modulating their activity would be extremely useful to elucidate the processes governing small-RNAs-guided gene silencing. We report the identification of a chemical compound able to compete with Argonaute 2 miRNAs binding, and we demonstrate that this functional inhibition determines effects similar to Argonaute 2 shRNA-mediated down-regulation, favoring granulocytic differentiation of the acute promyelocytic leukemia cell line NB4 in response to retinoic acid. © 2014 American Chemical Society.
Lingua originaleEnglish
pagine (da-a)1674-1679
Numero di pagine6
RivistaACS Chemical Biology
Volume9
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • Argonaute Proteins
  • Cell Differentiation
  • Cell Line, Tumor
  • Humans
  • Leukemia, Promyelocytic, Acute
  • MicroRNAs
  • Small Molecule Libraries
  • Tretinoin

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