A simulation environment for directional sensing as a phase separation process

Fausto Cavalli, Antonio De Candia, Andrea Gamba, Antonio Coniglio, Stefano Di Talia, Federico Bussolino, Guido Serini

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

4 Citazioni (Scopus)

Abstract

The ability of eukaryotic cells to navigate along spatial gradients of extracellular guidance cues is crucial for embryonic development, tissue regeneration, and cancer progression. One proposed model for chemotaxis is a phosphoinositide-based phase separation process, which takes place at the plasma membrane upon chemoattractant stimulation and triggers directional motility of eukaryotic cells. Here, we make available virtual-cell software that allows the execution and spatiotemporal analysis of in silico chemotaxis experiments, in which the user can control physical and chemical parameters as well as the number and position of chemoattractant sources.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaSCIENCE'S STKE: SIGNAL TRANSDUCTION KNOWLEDGE ENVIRONMENT
Volume2007
DOI
Stato di pubblicazionePubblicato - 2007

Keywords

  • Cell Membrane
  • Chemotactic Factors
  • Chemotaxis
  • Computer Simulation
  • Computer Systems
  • Cytosol
  • Data Display
  • Eukaryotic Cells
  • Membrane Lipids
  • Membrane Proteins
  • Microcomputers
  • Models, Biological
  • Osmolar Concentration
  • Phosphatidylinositols
  • Software
  • Stochastic Processes

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