A simulation environment for directional sensing as a phase separation process

Antonio De Candia; Andrea Gamba; Fausto Cavalli; Antonio Coniglio; Stefano Di Talia; Federico Bussolino; Guido Serini

doi:10.1126/stke.3782007pl1

A simulation environment for directional sensing as a phase separation process

Antonio De Candia, Andrea Gamba, Fausto Cavalli, Antonio Coniglio, Stefano Di Talia, Federico Bussolino, Guido Serini

Università Cattolica del Sacro Cuore

University of Naples Federico II

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

4 Citazioni (Scopus)

Abstract

The ability of eukaryotic cells to navigate along spatial gradients of extracellular guidance cues is crucial for embryonic development, tissue regeneration, and cancer progression. One proposed model for chemotaxis is a phosphoinositide-based phase separation process, which takes place at the plasma membrane upon chemoattractant stimulation and triggers directional motility of eukaryotic cells. Here, we make available virtual-cell software that allows the execution and spatiotemporal analysis of in silico chemotaxis experiments, in which the user can control physical and chemical parameters as well as the number and position of chemoattractant sources.

Lingua originale	English
pagine (da-a)	N/A-N/A
Rivista	SCIENCE'S STKE: SIGNAL TRANSDUCTION KNOWLEDGE ENVIRONMENT
Volume	2007
DOI	https://doi.org/10.1126/stke.3782007pl1
Stato di pubblicazione	Pubblicato - 2007

Keywords

Cell Membrane
Chemotactic Factors
Chemotaxis
Computer Simulation
Computer Systems
Cytosol
Data Display
Eukaryotic Cells
Membrane Lipids
Membrane Proteins
Microcomputers
Models, Biological
Osmolar Concentration
Phosphatidylinositols
Software
Stochastic Processes

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abstract = "The ability of eukaryotic cells to navigate along spatial gradients of extracellular guidance cues is crucial for embryonic development, tissue regeneration, and cancer progression. One proposed model for chemotaxis is a phosphoinositide-based phase separation process, which takes place at the plasma membrane upon chemoattractant stimulation and triggers directional motility of eukaryotic cells. Here, we make available virtual-cell software that allows the execution and spatiotemporal analysis of in silico chemotaxis experiments, in which the user can control physical and chemical parameters as well as the number and position of chemoattractant sources.",

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T1 - A simulation environment for directional sensing as a phase separation process

AU - De Candia, Antonio

AU - Gamba, Andrea

AU - Cavalli, Fausto

AU - Coniglio, Antonio

AU - Di Talia, Stefano

AU - Bussolino, Federico

AU - Serini, Guido

PY - 2007

Y1 - 2007

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AB - The ability of eukaryotic cells to navigate along spatial gradients of extracellular guidance cues is crucial for embryonic development, tissue regeneration, and cancer progression. One proposed model for chemotaxis is a phosphoinositide-based phase separation process, which takes place at the plasma membrane upon chemoattractant stimulation and triggers directional motility of eukaryotic cells. Here, we make available virtual-cell software that allows the execution and spatiotemporal analysis of in silico chemotaxis experiments, in which the user can control physical and chemical parameters as well as the number and position of chemoattractant sources.

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KW - Eukaryotic Cells

KW - Membrane Lipids

KW - Membrane Proteins

KW - Microcomputers

KW - Models, Biological

KW - Osmolar Concentration

KW - Phosphatidylinositols

KW - Software

KW - Stochastic Processes

UR - http://hdl.handle.net/10807/85717

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DO - 10.1126/stke.3782007pl1

M3 - Article

SN - 1525-8882

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JO - SCIENCE'S STKE: SIGNAL TRANSDUCTION KNOWLEDGE ENVIRONMENT

JF - SCIENCE'S STKE: SIGNAL TRANSDUCTION KNOWLEDGE ENVIRONMENT

ER -

A simulation environment for directional sensing as a phase separation process

Abstract

Keywords

OSS delle Nazioni Unite

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