A review of telomere length in sarcopenia and frailty

Roberto Bernabei, Graziano Onder, Silvia Giovannini, Stefano Bonassi, Teresa Lorenzi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

10 Citazioni (Scopus)

Abstract

Sarcopenia and frailty are associated with several important health-related adverse events, including disability, loss of independence, institutionalization and mortality. Sarcopenia can be considered a biological substrate of frailty, and the prevalence of both these conditions progressively increases with age. Telomeres are nucleoprotein structures located at the end of linear chromosomes and implicated in cellular ageing, shorten with age, and are associated with various age-related diseases. In addition, telomere length (TL) is widely considered a molecular/cellular hallmark of the ageing process. This narrative review summarizes the knowledge about telomeres and analyzes for the first time a possible association of TL with sarcopenia and frailty. The overview provided by the present review suggests that leukocyte TL as single measurement, calculated by quantitative real-time polymerase chain reaction (qRT-PCR), cannot be considered a meaningful biological marker for complex, multidimensional age-related conditions, such as sarcopenia and frailty. Panels of biomarkers, including TL, may provide more accurate assessment and prediction of outcomes in these geriatric syndromes in elderly people.
Lingua originaleEnglish
pagine (da-a)209-221
Numero di pagine13
RivistaBiogerontology
Volume19
DOI
Stato di pubblicazionePubblicato - 2018

Keywords

  • Age-related diseases
  • Ageing
  • Aging
  • Frailty
  • Geriatrics and Gerontology
  • Gerontology
  • Humans
  • Inflammation
  • Oxidative stress
  • Sarcopenia
  • Telomere Homeostasis
  • Telomere Shortening
  • Telomere length

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