A review of genetic epidemiology of head and neck cancer related to polymorphisms in metabolic genes, cell cycle control and alcohol metabolism

Gabriella Cadoni; Stefania Boccia; Livia Petrelli; Paolo Di Giannantonio; Dario Arzani; Arianna Giorgio; Emma De Feo; Manlio Pandolfini; Paola Galli'; Gaetano Paludetti; Walter Ricciardi

A review of genetic epidemiology of head and neck cancer related to polymorphisms in metabolic genes, cell cycle control and alcohol metabolism

Gabriella Cadoni, Stefania Boccia, Livia Petrelli, Paolo Di Giannantonio, Dario Arzani, Arianna Giorgio, Emma De Feo, Manlio Pandolfini, Paola Galli', Gaetano Paludetti, Walter Ricciardi

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Abstract

The purpose of this report is to review the relationship between genetic polymorphisms involved in carcinogen metabolism, alcohol metabolism and cell-cycle control with the risk of head and neck cancer. The review was performed on available studies on genetic polymorphisms and head and neck cancer (HNC) published in PubMed up to September 2011. 246 primary articles and 7 meta-analyses were published. Among these, a statistically significant association was reported for glutathione S-transferases (GSTM1), glutathione S-transferases (GSTT1) and human microsomal epoxide hydrolase (EPHX1) genes. An increased risk for HNC was also associated reported for P53 codon 72 Pro/Pro, ALDH2 and three variants of the ADH gene: ADH1B (rs1229984), ADH7 (rs1573496) and ADH1C (rs698).

Lingua originale	Inglese
pagine (da-a)	1-11
Numero di pagine	11
Rivista	Acta Otorhinolaryngologica Italica
Volume	32
Stato di pubblicazione	Pubblicato - 2012

Keywords

genetic polymorphisms
genetic susceptibilty
head and neck cancer

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title = "A review of genetic epidemiology of head and neck cancer related to polymorphisms in metabolic genes, cell cycle control and alcohol metabolism",

abstract = "The purpose of this report is to review the relationship between genetic polymorphisms involved in carcinogen metabolism, alcohol metabolism and cell-cycle control with the risk of head and neck cancer. The review was performed on available studies on genetic polymorphisms and head and neck cancer (HNC) published in PubMed up to September 2011. 246 primary articles and 7 meta-analyses were published. Among these, a statistically significant association was reported for glutathione S-transferases (GSTM1), glutathione S-transferases (GSTT1) and human microsomal epoxide hydrolase (EPHX1) genes. An increased risk for HNC was also associated reported for P53 codon 72 Pro/Pro, ALDH2 and three variants of the ADH gene: ADH1B (rs1229984), ADH7 (rs1573496) and ADH1C (rs698).",

keywords = "genetic polymorphisms, genetic susceptibilty, head and neck cancer, genetic polymorphisms, genetic susceptibilty, head and neck cancer",

author = "Gabriella Cadoni and Stefania Boccia and Livia Petrelli and \{Di Giannantonio\}, Paolo and Dario Arzani and Arianna Giorgio and \{De Feo\}, Emma and Manlio Pandolfini and Paola Galli' and Gaetano Paludetti and Walter Ricciardi",

year = "2012",

language = "English",

volume = "32",

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journal = "Acta Otorhinolaryngologica Italica",

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TY - JOUR

T1 - A review of genetic epidemiology of head and neck cancer related to polymorphisms in metabolic genes, cell cycle control and alcohol metabolism

AU - Cadoni, Gabriella

AU - Boccia, Stefania

AU - Petrelli, Livia

AU - Di Giannantonio, Paolo

AU - Arzani, Dario

AU - Giorgio, Arianna

AU - De Feo, Emma

AU - Pandolfini, Manlio

AU - Galli', Paola

AU - Paludetti, Gaetano

AU - Ricciardi, Walter

PY - 2012

Y1 - 2012

N2 - The purpose of this report is to review the relationship between genetic polymorphisms involved in carcinogen metabolism, alcohol metabolism and cell-cycle control with the risk of head and neck cancer. The review was performed on available studies on genetic polymorphisms and head and neck cancer (HNC) published in PubMed up to September 2011. 246 primary articles and 7 meta-analyses were published. Among these, a statistically significant association was reported for glutathione S-transferases (GSTM1), glutathione S-transferases (GSTT1) and human microsomal epoxide hydrolase (EPHX1) genes. An increased risk for HNC was also associated reported for P53 codon 72 Pro/Pro, ALDH2 and three variants of the ADH gene: ADH1B (rs1229984), ADH7 (rs1573496) and ADH1C (rs698).

AB - The purpose of this report is to review the relationship between genetic polymorphisms involved in carcinogen metabolism, alcohol metabolism and cell-cycle control with the risk of head and neck cancer. The review was performed on available studies on genetic polymorphisms and head and neck cancer (HNC) published in PubMed up to September 2011. 246 primary articles and 7 meta-analyses were published. Among these, a statistically significant association was reported for glutathione S-transferases (GSTM1), glutathione S-transferases (GSTT1) and human microsomal epoxide hydrolase (EPHX1) genes. An increased risk for HNC was also associated reported for P53 codon 72 Pro/Pro, ALDH2 and three variants of the ADH gene: ADH1B (rs1229984), ADH7 (rs1573496) and ADH1C (rs698).

KW - genetic polymorphisms

KW - genetic susceptibilty

KW - head and neck cancer

KW - genetic polymorphisms

KW - genetic susceptibilty

KW - head and neck cancer

UR - http://hdl.handle.net/10807/6123

M3 - Article

SN - 1827-675X

VL - 32

SP - 1

EP - 11

JO - Acta Otorhinolaryngologica Italica

JF - Acta Otorhinolaryngologica Italica

ER -

A review of genetic epidemiology of head and neck cancer related to polymorphisms in metabolic genes, cell cycle control and alcohol metabolism

Abstract

Keywords

OSS delle Nazioni Unite

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