This literature review discusses the current evidence on acute limb ischemia (ALI) in patients with COVID-19. Throughout the pandemic, these patients have been at increased risk of arterial thrombotic events and subsequent mortality as a result of a hypercoagulable state. The exact mechanism of thrombosis is unknown; however arterial thrombosis may be due to invasion of endothelial cells via angiotensin-converting enzyme 2 (ACE2) receptors, endothelial injury from inflammation, or even free-floating aortic thrombus. Multiple studies have been performed evaluating the medical and surgical management of these patients; the decision to proceed with operative intervention is dependent on the patient's clinical status as it relates to COVID-19 and morbidity of that disease. The interventions afforded typically include anticoagulation in patients undergoing palliation; alternatively, thrombectomy (endovascular and open) is utilized in other patients. There is a high risk of rethrombosis, despite anticoagulation, given persistent endothelial injury from the virus. Postoperative mortality can be high in these patients.
Lingua originaleEnglish
pagine (da-a)8-12
Numero di pagine5
RivistaSeminars in Vascular Surgery
Stato di pubblicazionePubblicato - 2021


  • Anticoagulants
  • COVID-19
  • Humans
  • Ischemia
  • Lower Extremity
  • Mixing efficiency
  • Rayleigh-Taylor instability
  • Stratification
  • Thrombectomy
  • Thrombosis


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