TY - JOUR
T1 - A Randomized controlled study on effects of ibuprofen on cognitive progression of Alzheimer's disease
AU - Pasqualetti, Patrizio
AU - Bonomini, Cristina
AU - Dal Forno, Gloria
AU - Paulon, Luca
AU - Sinforiani, Elena
AU - Marra, Camillo
AU - Zanetti, Orazio
AU - Rossini, Paolo Maria
PY - 2009
Y1 - 2009
N2 - Epidemiological studies have examined the association between the use of non-steroidal anti-inflammatory drugs (NSAIDs) and the risk of Alzheimer's disease (AD). Recently, a variety of experimental studies indicates that a subset of NSAIDs, such as ibuprofen or flurbiprofen, also have Abeta-lowering properties in both AD transgenic mice and cell cultures of peripheral, glial and neuronal origin. In this trial, we evaluated whether the non-selective NSAID ibuprofen slows disease progression in patients with mild to moderate AD.
AB - Epidemiological studies have examined the association between the use of non-steroidal anti-inflammatory drugs (NSAIDs) and the risk of Alzheimer's disease (AD). Recently, a variety of experimental studies indicates that a subset of NSAIDs, such as ibuprofen or flurbiprofen, also have Abeta-lowering properties in both AD transgenic mice and cell cultures of peripheral, glial and neuronal origin. In this trial, we evaluated whether the non-selective NSAID ibuprofen slows disease progression in patients with mild to moderate AD.
KW - APOE e4
KW - Alzheimer Disease
KW - APOE e4
KW - Alzheimer Disease
UR - https://publicatt.unicatt.it/handle/10807/37929
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=66849143701&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=66849143701&origin=inward
U2 - 10.1007/BF03325217
DO - 10.1007/BF03325217
M3 - Article
SN - 1720-8319
VL - 21
SP - 102
EP - 110
JO - Aging clinical and experimental research
JF - Aging clinical and experimental research
IS - 2
ER -