A Randomized controlled study on effects of ibuprofen on cognitive progression of Alzheimer's disease

Patrizio Pasqualetti; Cristina Bonomini; Gloria Dal Forno; Luca Paulon; Elena Sinforiani; Camillo Marra; Orazio Zanetti; Paolo Maria Rossini

doi:10.1007/BF03325217

A Randomized controlled study on effects of ibuprofen on cognitive progression of Alzheimer's disease

Patrizio Pasqualetti, Cristina Bonomini, Gloria Dal Forno, Luca Paulon, Elena Sinforiani, Camillo Marra, Orazio Zanetti, Paolo Maria Rossini

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

115 Citazioni (Scopus)

Abstract

Epidemiological studies have examined the association between the use of non-steroidal anti-inflammatory drugs (NSAIDs) and the risk of Alzheimer's disease (AD). Recently, a variety of experimental studies indicates that a subset of NSAIDs, such as ibuprofen or flurbiprofen, also have Abeta-lowering properties in both AD transgenic mice and cell cultures of peripheral, glial and neuronal origin. In this trial, we evaluated whether the non-selective NSAID ibuprofen slows disease progression in patients with mild to moderate AD.

Lingua originale	English
pagine (da-a)	102-110
Numero di pagine	8
Rivista	Aging clinical and experimental research
Volume	21
DOI	https://doi.org/10.1007/BF03325217
Stato di pubblicazione	Pubblicato - 2009

Keywords

APOE e4
Alzheimer Disease

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10.1007/BF03325217

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abstract = "Epidemiological studies have examined the association between the use of non-steroidal anti-inflammatory drugs (NSAIDs) and the risk of Alzheimer's disease (AD). Recently, a variety of experimental studies indicates that a subset of NSAIDs, such as ibuprofen or flurbiprofen, also have Abeta-lowering properties in both AD transgenic mice and cell cultures of peripheral, glial and neuronal origin. In this trial, we evaluated whether the non-selective NSAID ibuprofen slows disease progression in patients with mild to moderate AD.",

keywords = "APOE e4, Alzheimer Disease, APOE e4, Alzheimer Disease",

author = "Patrizio Pasqualetti and Cristina Bonomini and {Dal Forno}, Gloria and Luca Paulon and Elena Sinforiani and Camillo Marra and Orazio Zanetti and Rossini, {Paolo Maria}",

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doi = "10.1007/BF03325217",

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T1 - A Randomized controlled study on effects of ibuprofen on cognitive progression of Alzheimer's disease

AU - Pasqualetti, Patrizio

AU - Bonomini, Cristina

AU - Dal Forno, Gloria

AU - Paulon, Luca

AU - Sinforiani, Elena

AU - Marra, Camillo

AU - Zanetti, Orazio

AU - Rossini, Paolo Maria

PY - 2009

Y1 - 2009

N2 - Epidemiological studies have examined the association between the use of non-steroidal anti-inflammatory drugs (NSAIDs) and the risk of Alzheimer's disease (AD). Recently, a variety of experimental studies indicates that a subset of NSAIDs, such as ibuprofen or flurbiprofen, also have Abeta-lowering properties in both AD transgenic mice and cell cultures of peripheral, glial and neuronal origin. In this trial, we evaluated whether the non-selective NSAID ibuprofen slows disease progression in patients with mild to moderate AD.

AB - Epidemiological studies have examined the association between the use of non-steroidal anti-inflammatory drugs (NSAIDs) and the risk of Alzheimer's disease (AD). Recently, a variety of experimental studies indicates that a subset of NSAIDs, such as ibuprofen or flurbiprofen, also have Abeta-lowering properties in both AD transgenic mice and cell cultures of peripheral, glial and neuronal origin. In this trial, we evaluated whether the non-selective NSAID ibuprofen slows disease progression in patients with mild to moderate AD.

KW - APOE e4

KW - Alzheimer Disease

KW - APOE e4

KW - Alzheimer Disease

UR - http://hdl.handle.net/10807/37929

U2 - 10.1007/BF03325217

DO - 10.1007/BF03325217

M3 - Article

SN - 1720-8319

VL - 21

SP - 102

EP - 110

JO - Aging clinical and experimental research

JF - Aging clinical and experimental research

ER -

A Randomized controlled study on effects of ibuprofen on cognitive progression of Alzheimer's disease

Abstract

Keywords

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