A Randomized controlled study on effects of ibuprofen on cognitive progression of Alzheimer's disease

Camillo Marra, Paolo Maria Rossini, Patrizio Pasqualetti, Cristina Bonomini, Gloria Dal Forno, Luca Paulon, Elena Sinforiani, Orazio Zanetti

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

110 Citazioni (Scopus)

Abstract

Epidemiological studies have examined the association between the use of non-steroidal anti-inflammatory drugs (NSAIDs) and the risk of Alzheimer's disease (AD). Recently, a variety of experimental studies indicates that a subset of NSAIDs, such as ibuprofen or flurbiprofen, also have Abeta-lowering properties in both AD transgenic mice and cell cultures of peripheral, glial and neuronal origin. In this trial, we evaluated whether the non-selective NSAID ibuprofen slows disease progression in patients with mild to moderate AD.
Lingua originaleEnglish
pagine (da-a)21-28
Numero di pagine8
RivistaAging clinical and experimental research
Stato di pubblicazionePubblicato - 2009

Keywords

  • APOE e4
  • Alzheimer Disease

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