A prospective survey of febrile events in hematological malignancies

Livio Pagano; Morena Caira; G Rossi; Mario Tumbarello; R Fanci; Mg Garzia; N Vianelli; N Filardi; P De Fabritiis; A Beltrame; M Musso; A Piccin; A Cuneo; Chiara Cattaneo; T Aloisi; M Riva; G Rossi; U Salvadori; M Brugiatelli; S Sannicolò; M Morselli; A Bonini; P Viale; A Nosari; F Aversa; Chart Group Hema E.

doi:10.1007/s00277-011-1373-2

A prospective survey of febrile events in hematological malignancies

Livio Pagano, Morena Caira, G Rossi, Mario Tumbarello, R Fanci, Mg Garzia, N Vianelli, N Filardi, P De Fabritiis, A Beltrame, M Musso, A Piccin, A Cuneo, Chiara Cattaneo, T Aloisi, M Riva, G Rossi, U Salvadori, M Brugiatelli, S SannicolòM Morselli, A Bonini, P Viale, A Nosari, F Aversa, Chart Group Hema E.

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

Abstract

The Hema e-Chart prospectively collected data on febrile events (FEs) in hematological malignancy patients (HMs). The aim of the study was to assess the number, causes and outcome of HM-related FEs. Data were collected in a computerized registry that systematically approached the study and the evolution of FEs developing in a cohort of adult HMs who were admitted to 19 hematology departments in Italy from March 2007 to December 2008. A total of 869 FEs in 3,197 patients with newly diagnosed HMs were recorded. Fever of unidentified origin (FUO) was observed in 386 cases (44.4%). The other causes of FE were identified as noninfectious in 48 cases (5.5%) and infectious in 435 cases (50.1%). Bacteria were the most common cause of infectious FEs (301 cases), followed by fungi (95 cases), and viruses (7 cases). Mixed agents were isolated in 32 episodes. The attributable mortality rate was 6.7% (58 FEs). No deaths were observed in viral infection or in the noninfectious groups, while 25 deaths were due to FUO, 16 to bacterial infections, 14 to fungal infections, and three to mixed infections. The Hema e-Chart provided a complete system for the epidemiological study of infectious complications in HMs.

Lingua originale	English
pagine (da-a)	767-774
Numero di pagine	8
Rivista	Annals of Hematology
Volume	2012
DOI	https://doi.org/10.1007/s00277-011-1373-2
Stato di pubblicazione	Pubblicato - 2012

Keywords

FEBRILE EVENTS
HEMATOLOGICAL

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10.1007/s00277-011-1373-2

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Pagano, L., Caira, M., Rossi, G., Tumbarello, M., Fanci, R., Garzia, M., Vianelli, N., Filardi, N., De Fabritiis, P., Beltrame, A., Musso, M., Piccin, A., Cuneo, A., Cattaneo, C., Aloisi, T., Riva, M., Rossi, G., Salvadori, U., Brugiatelli, M., ... Hema E., C. G. (2012). A prospective survey of febrile events in hematological malignancies. Annals of Hematology, 2012, 767-774. https://doi.org/10.1007/s00277-011-1373-2

@article{dad18df06b0a42ff865e54cceaa5992b,

title = "A prospective survey of febrile events in hematological malignancies",

abstract = "The Hema e-Chart prospectively collected data on febrile events (FEs) in hematological malignancy patients (HMs). The aim of the study was to assess the number, causes and outcome of HM-related FEs. Data were collected in a computerized registry that systematically approached the study and the evolution of FEs developing in a cohort of adult HMs who were admitted to 19 hematology departments in Italy from March 2007 to December 2008. A total of 869 FEs in 3,197 patients with newly diagnosed HMs were recorded. Fever of unidentified origin (FUO) was observed in 386 cases (44.4%). The other causes of FE were identified as noninfectious in 48 cases (5.5%) and infectious in 435 cases (50.1%). Bacteria were the most common cause of infectious FEs (301 cases), followed by fungi (95 cases), and viruses (7 cases). Mixed agents were isolated in 32 episodes. The attributable mortality rate was 6.7% (58 FEs). No deaths were observed in viral infection or in the noninfectious groups, while 25 deaths were due to FUO, 16 to bacterial infections, 14 to fungal infections, and three to mixed infections. The Hema e-Chart provided a complete system for the epidemiological study of infectious complications in HMs.",

keywords = "FEBRILE EVENTS, HEMATOLOGICAL, FEBRILE EVENTS, HEMATOLOGICAL",

author = "Livio Pagano and Morena Caira and G Rossi and Mario Tumbarello and R Fanci and Mg Garzia and N Vianelli and N Filardi and {De Fabritiis}, P and A Beltrame and M Musso and A Piccin and A Cuneo and Chiara Cattaneo and T Aloisi and M Riva and G Rossi and U Salvadori and M Brugiatelli and S Sannicol{\`o} and M Morselli and A Bonini and P Viale and A Nosari and F Aversa and {Hema E.}, {Chart Group}",

year = "2012",

doi = "10.1007/s00277-011-1373-2",

language = "English",

volume = "2012",

pages = "767--774",

journal = "Annals of Hematology",

issn = "0939-5555",

publisher = "Springer Science and Business Media Deutschland GmbH",

}

Pagano, L, Caira, M, Rossi, G, Tumbarello, M, Fanci, R, Garzia, M, Vianelli, N, Filardi, N, De Fabritiis, P, Beltrame, A, Musso, M, Piccin, A, Cuneo, A, Cattaneo, C, Aloisi, T, Riva, M, Rossi, G, Salvadori, U, Brugiatelli, M, Sannicolò, S, Morselli, M, Bonini, A, Viale, P, Nosari, A, Aversa, F & Hema E., CG 2012, 'A prospective survey of febrile events in hematological malignancies', Annals of Hematology, vol. 2012, pagg. 767-774. https://doi.org/10.1007/s00277-011-1373-2

TY - JOUR

T1 - A prospective survey of febrile events in hematological malignancies

AU - Pagano, Livio

AU - Caira, Morena

AU - Rossi, G

AU - Tumbarello, Mario

AU - Fanci, R

AU - Garzia, Mg

AU - Vianelli, N

AU - Filardi, N

AU - De Fabritiis, P

AU - Beltrame, A

AU - Musso, M

AU - Piccin, A

AU - Cuneo, A

AU - Cattaneo, Chiara

AU - Aloisi, T

AU - Riva, M

AU - Rossi, G

AU - Salvadori, U

AU - Brugiatelli, M

AU - Sannicolò, S

AU - Morselli, M

AU - Bonini, A

AU - Viale, P

AU - Nosari, A

AU - Aversa, F

AU - Hema E., Chart Group

PY - 2012

Y1 - 2012

N2 - The Hema e-Chart prospectively collected data on febrile events (FEs) in hematological malignancy patients (HMs). The aim of the study was to assess the number, causes and outcome of HM-related FEs. Data were collected in a computerized registry that systematically approached the study and the evolution of FEs developing in a cohort of adult HMs who were admitted to 19 hematology departments in Italy from March 2007 to December 2008. A total of 869 FEs in 3,197 patients with newly diagnosed HMs were recorded. Fever of unidentified origin (FUO) was observed in 386 cases (44.4%). The other causes of FE were identified as noninfectious in 48 cases (5.5%) and infectious in 435 cases (50.1%). Bacteria were the most common cause of infectious FEs (301 cases), followed by fungi (95 cases), and viruses (7 cases). Mixed agents were isolated in 32 episodes. The attributable mortality rate was 6.7% (58 FEs). No deaths were observed in viral infection or in the noninfectious groups, while 25 deaths were due to FUO, 16 to bacterial infections, 14 to fungal infections, and three to mixed infections. The Hema e-Chart provided a complete system for the epidemiological study of infectious complications in HMs.

AB - The Hema e-Chart prospectively collected data on febrile events (FEs) in hematological malignancy patients (HMs). The aim of the study was to assess the number, causes and outcome of HM-related FEs. Data were collected in a computerized registry that systematically approached the study and the evolution of FEs developing in a cohort of adult HMs who were admitted to 19 hematology departments in Italy from March 2007 to December 2008. A total of 869 FEs in 3,197 patients with newly diagnosed HMs were recorded. Fever of unidentified origin (FUO) was observed in 386 cases (44.4%). The other causes of FE were identified as noninfectious in 48 cases (5.5%) and infectious in 435 cases (50.1%). Bacteria were the most common cause of infectious FEs (301 cases), followed by fungi (95 cases), and viruses (7 cases). Mixed agents were isolated in 32 episodes. The attributable mortality rate was 6.7% (58 FEs). No deaths were observed in viral infection or in the noninfectious groups, while 25 deaths were due to FUO, 16 to bacterial infections, 14 to fungal infections, and three to mixed infections. The Hema e-Chart provided a complete system for the epidemiological study of infectious complications in HMs.

KW - FEBRILE EVENTS

KW - HEMATOLOGICAL

KW - FEBRILE EVENTS

KW - HEMATOLOGICAL

UR - http://hdl.handle.net/10807/5774

U2 - 10.1007/s00277-011-1373-2

DO - 10.1007/s00277-011-1373-2

M3 - Article

SN - 0939-5555

VL - 2012

SP - 767

EP - 774

JO - Annals of Hematology

JF - Annals of Hematology

ER -

A prospective survey of febrile events in hematological malignancies

Abstract

Keywords

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