A PLAG1 mutation contributed to stature recovery in modern cattle

Licia Colli; Paolo Ajmone Marsan; Marco Sannazaro; Elisa Eufemi; Yuri Tani Utsunomiya; Adam Taiti Harth Utsunomiya; Rafaela Beatriz Pintor Torrecilha; Eui-Soo Kim; Márcio Silva Costa; Tamíris Sayuri Aguiar; Steven Schroeder; Adriana Santana Do Carmo; Roberto Carvalheiro; Haroldo Henrique Rezende Neves; Romulo Cláudio Morozini Padula; Thayla Souza Sussai; Ludmilla Balbo Zavarez; Rafael Silva Cipriano; Maria Margareth Theodoro Caminhas; George Hambrecht; Maurizio Buora; Michele Morgante; George Liu; Derek Bickhart; Curtis Paul Van Tassell; Johann Sölkner; Tad Stewart Sonstegard; José Fernando Garcia

doi:10.1038/s41598-017-17127-1

A PLAG1 mutation contributed to stature recovery in modern cattle

Licia Colli, Paolo Ajmone Marsan, Marco Sannazaro, Elisa Eufemi, Yuri Tani Utsunomiya, Adam Taiti Harth Utsunomiya, Rafaela Beatriz Pintor Torrecilha, Eui-Soo Kim, Márcio Silva Costa, Tamíris Sayuri Aguiar, Steven Schroeder, Adriana Santana Do Carmo, Roberto Carvalheiro, Haroldo Henrique Rezende Neves, Romulo Cláudio Morozini Padula, Thayla Souza Sussai, Ludmilla Balbo Zavarez, Rafael Silva Cipriano, Maria Margareth Theodoro Caminhas, George HambrechtMaurizio Buora, Michele Morgante, George Liu, Derek Bickhart, Curtis Paul Van Tassell, Johann Sölkner, Tad Stewart Sonstegard, José Fernando Garcia

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

26 Citazioni (Scopus)

Abstract

The recent evolution of cattle is marked by fluctuations in body size. Height in the Bos taurus lineage was reduced by a factor of â¼1.5 from the Neolithic to the Middle Ages, and increased again only during the Early Modern Ages. Using haplotype analysis, we found evidence that the bovine PLAG1 mutation (Q) with major effects on body size, weight and reproduction is a >1,000 years old derived allele that increased rapidly in frequency in Northwestern European B. taurus between the 16thand 18thcenturies. Towards the 19thand 20thcenturies, Q was introgressed into non-European B. taurus and Bos indicus breeds. These data implicate a major role of Q in recent changes in body size in modern cattle, and represent one of the first examples of a genomic sweep in livestock that was driven by selection on a complex trait.

Lingua originale	English
pagine (da-a)	17140-N/A
Rivista	Scientific Reports
Volume	7
DOI	https://doi.org/10.1038/s41598-017-17127-1
Stato di pubblicazione	Pubblicato - 2017

Keywords

Multidisciplinary

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10.1038/s41598-017-17127-1

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Colli, L., Ajmone Marsan, P., Sannazaro, M., Eufemi, E., Utsunomiya, Y. T., Utsunomiya, A. T. H., Torrecilha, R. B. P., Kim, E-S., Costa, M. S., Aguiar, T. S., Schroeder, S., Do Carmo, A. S., Carvalheiro, R., Neves, H. H. R., Padula, R. C. M., Sussai, T. S., Zavarez, L. B., Cipriano, R. S., Caminhas, M. M. T., ... Garcia, J. F. (2017). A PLAG1 mutation contributed to stature recovery in modern cattle. Scientific Reports, 7, 17140-N/A. https://doi.org/10.1038/s41598-017-17127-1

Colli, Licia ; Ajmone Marsan, Paolo ; Sannazaro, Marco ; Eufemi, Elisa ; Utsunomiya, Yuri Tani ; Utsunomiya, Adam Taiti Harth ; Torrecilha, Rafaela Beatriz Pintor ; Kim, Eui-Soo ; Costa, Márcio Silva ; Aguiar, Tamíris Sayuri ; Schroeder, Steven ; Do Carmo, Adriana Santana ; Carvalheiro, Roberto ; Neves, Haroldo Henrique Rezende ; Padula, Romulo Cláudio Morozini ; Sussai, Thayla Souza ; Zavarez, Ludmilla Balbo ; Cipriano, Rafael Silva ; Caminhas, Maria Margareth Theodoro ; Hambrecht, George ; Buora, Maurizio ; Morgante, Michele ; Liu, George ; Bickhart, Derek ; Van Tassell, Curtis Paul ; Sölkner, Johann ; Sonstegard, Tad Stewart ; Garcia, José Fernando. / A PLAG1 mutation contributed to stature recovery in modern cattle. In: Scientific Reports. 2017 ; Vol. 7. pagg. 17140-N/A.

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title = "A PLAG1 mutation contributed to stature recovery in modern cattle",

abstract = "The recent evolution of cattle is marked by fluctuations in body size. Height in the Bos taurus lineage was reduced by a factor of {\^a}¼1.5 from the Neolithic to the Middle Ages, and increased again only during the Early Modern Ages. Using haplotype analysis, we found evidence that the bovine PLAG1 mutation (Q) with major effects on body size, weight and reproduction is a >1,000 years old derived allele that increased rapidly in frequency in Northwestern European B. taurus between the 16thand 18thcenturies. Towards the 19thand 20thcenturies, Q was introgressed into non-European B. taurus and Bos indicus breeds. These data implicate a major role of Q in recent changes in body size in modern cattle, and represent one of the first examples of a genomic sweep in livestock that was driven by selection on a complex trait.",

keywords = "Multidisciplinary, Multidisciplinary",

author = "Licia Colli and {Ajmone Marsan}, Paolo and Marco Sannazaro and Elisa Eufemi and Utsunomiya, {Yuri Tani} and Utsunomiya, {Adam Taiti Harth} and Torrecilha, {Rafaela Beatriz Pintor} and Eui-Soo Kim and Costa, {M{\'a}rcio Silva} and Aguiar, {Tam{\'i}ris Sayuri} and Steven Schroeder and {Do Carmo}, {Adriana Santana} and Roberto Carvalheiro and Neves, {Haroldo Henrique Rezende} and Padula, {Romulo Cl{\'a}udio Morozini} and Sussai, {Thayla Souza} and Zavarez, {Ludmilla Balbo} and Cipriano, {Rafael Silva} and Caminhas, {Maria Margareth Theodoro} and George Hambrecht and Maurizio Buora and Michele Morgante and George Liu and Derek Bickhart and {Van Tassell}, {Curtis Paul} and Johann S{\"o}lkner and Sonstegard, {Tad Stewart} and Garcia, {Jos{\'e} Fernando}",

year = "2017",

doi = "10.1038/s41598-017-17127-1",

language = "English",

volume = "7",

pages = "17140--N/A",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "London : Nature Publishing Group",

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Colli, L , Ajmone Marsan, P , Sannazaro, M, Eufemi, E, Utsunomiya, YT, Utsunomiya, ATH, Torrecilha, RBP, Kim, E-S, Costa, MS, Aguiar, TS, Schroeder, S, Do Carmo, AS, Carvalheiro, R, Neves, HHR, Padula, RCM, Sussai, TS, Zavarez, LB, Cipriano, RS, Caminhas, MMT, Hambrecht, G, Buora, M, Morgante, M, Liu, G, Bickhart, D, Van Tassell, CP, Sölkner, J, Sonstegard, TS & Garcia, JF 2017, 'A PLAG1 mutation contributed to stature recovery in modern cattle', Scientific Reports, vol. 7, pagg. 17140-N/A. https://doi.org/10.1038/s41598-017-17127-1

A PLAG1 mutation contributed to stature recovery in modern cattle. / Colli, Licia ; Ajmone Marsan, Paolo ; Sannazaro, Marco; Eufemi, Elisa; Utsunomiya, Yuri Tani; Utsunomiya, Adam Taiti Harth; Torrecilha, Rafaela Beatriz Pintor; Kim, Eui-Soo; Costa, Márcio Silva; Aguiar, Tamíris Sayuri; Schroeder, Steven; Do Carmo, Adriana Santana; Carvalheiro, Roberto; Neves, Haroldo Henrique Rezende; Padula, Romulo Cláudio Morozini; Sussai, Thayla Souza; Zavarez, Ludmilla Balbo; Cipriano, Rafael Silva; Caminhas, Maria Margareth Theodoro; Hambrecht, George; Buora, Maurizio; Morgante, Michele; Liu, George; Bickhart, Derek; Van Tassell, Curtis Paul; Sölkner, Johann; Sonstegard, Tad Stewart; Garcia, José Fernando.

In: Scientific Reports, Vol. 7, 2017, pag. 17140-N/A.

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

TY - JOUR

T1 - A PLAG1 mutation contributed to stature recovery in modern cattle

AU - Colli, Licia

AU - Ajmone Marsan, Paolo

AU - Sannazaro, Marco

AU - Eufemi, Elisa

AU - Utsunomiya, Yuri Tani

AU - Utsunomiya, Adam Taiti Harth

AU - Torrecilha, Rafaela Beatriz Pintor

AU - Kim, Eui-Soo

AU - Costa, Márcio Silva

AU - Aguiar, Tamíris Sayuri

AU - Schroeder, Steven

AU - Do Carmo, Adriana Santana

AU - Carvalheiro, Roberto

AU - Neves, Haroldo Henrique Rezende

AU - Padula, Romulo Cláudio Morozini

AU - Sussai, Thayla Souza

AU - Zavarez, Ludmilla Balbo

AU - Cipriano, Rafael Silva

AU - Caminhas, Maria Margareth Theodoro

AU - Hambrecht, George

AU - Buora, Maurizio

AU - Morgante, Michele

AU - Liu, George

AU - Bickhart, Derek

AU - Van Tassell, Curtis Paul

AU - Sölkner, Johann

AU - Sonstegard, Tad Stewart

AU - Garcia, José Fernando

PY - 2017

Y1 - 2017

N2 - The recent evolution of cattle is marked by fluctuations in body size. Height in the Bos taurus lineage was reduced by a factor of â¼1.5 from the Neolithic to the Middle Ages, and increased again only during the Early Modern Ages. Using haplotype analysis, we found evidence that the bovine PLAG1 mutation (Q) with major effects on body size, weight and reproduction is a >1,000 years old derived allele that increased rapidly in frequency in Northwestern European B. taurus between the 16thand 18thcenturies. Towards the 19thand 20thcenturies, Q was introgressed into non-European B. taurus and Bos indicus breeds. These data implicate a major role of Q in recent changes in body size in modern cattle, and represent one of the first examples of a genomic sweep in livestock that was driven by selection on a complex trait.

AB - The recent evolution of cattle is marked by fluctuations in body size. Height in the Bos taurus lineage was reduced by a factor of â¼1.5 from the Neolithic to the Middle Ages, and increased again only during the Early Modern Ages. Using haplotype analysis, we found evidence that the bovine PLAG1 mutation (Q) with major effects on body size, weight and reproduction is a >1,000 years old derived allele that increased rapidly in frequency in Northwestern European B. taurus between the 16thand 18thcenturies. Towards the 19thand 20thcenturies, Q was introgressed into non-European B. taurus and Bos indicus breeds. These data implicate a major role of Q in recent changes in body size in modern cattle, and represent one of the first examples of a genomic sweep in livestock that was driven by selection on a complex trait.

KW - Multidisciplinary

UR - http://hdl.handle.net/10807/116042

UR - http://www.nature.com/srep/index.html

U2 - 10.1038/s41598-017-17127-1

DO - 10.1038/s41598-017-17127-1

M3 - Article

VL - 7

SP - 17140-N/A

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

ER -

A PLAG1 mutation contributed to stature recovery in modern cattle

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