TY - JOUR
T1 - A PLAG1 mutation contributed to stature recovery in modern cattle
AU - Colli, Licia
AU - Ajmone Marsan, Paolo
AU - Sannazaro, Marco
AU - Eufemi, Elisa
AU - Utsunomiya, Yuri Tani
AU - Utsunomiya, Adam Taiti Harth
AU - Torrecilha, Rafaela Beatriz Pintor
AU - Kim, Eui-Soo
AU - Costa, Márcio Silva
AU - Aguiar, Tamíris Sayuri
AU - Schroeder, Steven
AU - Do Carmo, Adriana Santana
AU - Carvalheiro, Roberto
AU - Neves, Haroldo Henrique Rezende
AU - Padula, Romulo Cláudio Morozini
AU - Sussai, Thayla Souza
AU - Zavarez, Ludmilla Balbo
AU - Cipriano, Rafael Silva
AU - Caminhas, Maria Margareth Theodoro
AU - Hambrecht, George
AU - Buora, Maurizio
AU - Morgante, Michele
AU - Liu, George
AU - Bickhart, Derek
AU - Van Tassell, Curtis Paul
AU - Sölkner, Johann
AU - Sonstegard, Tad Stewart
AU - Garcia, José Fernando
PY - 2017
Y1 - 2017
N2 - The recent evolution of cattle is marked by fluctuations in body size. Height in the Bos taurus lineage was reduced by a factor of â¼1.5 from the Neolithic to the Middle Ages, and increased again only during the Early Modern Ages. Using haplotype analysis, we found evidence that the bovine PLAG1 mutation (Q) with major effects on body size, weight and reproduction is a >1,000 years old derived allele that increased rapidly in frequency in Northwestern European B. taurus between the 16thand 18thcenturies. Towards the 19thand 20thcenturies, Q was introgressed into non-European B. taurus and Bos indicus breeds. These data implicate a major role of Q in recent changes in body size in modern cattle, and represent one of the first examples of a genomic sweep in livestock that was driven by selection on a complex trait.
AB - The recent evolution of cattle is marked by fluctuations in body size. Height in the Bos taurus lineage was reduced by a factor of â¼1.5 from the Neolithic to the Middle Ages, and increased again only during the Early Modern Ages. Using haplotype analysis, we found evidence that the bovine PLAG1 mutation (Q) with major effects on body size, weight and reproduction is a >1,000 years old derived allele that increased rapidly in frequency in Northwestern European B. taurus between the 16thand 18thcenturies. Towards the 19thand 20thcenturies, Q was introgressed into non-European B. taurus and Bos indicus breeds. These data implicate a major role of Q in recent changes in body size in modern cattle, and represent one of the first examples of a genomic sweep in livestock that was driven by selection on a complex trait.
KW - Multidisciplinary
KW - Multidisciplinary
UR - http://hdl.handle.net/10807/116042
UR - http://www.nature.com/srep/index.html
U2 - 10.1038/s41598-017-17127-1
DO - 10.1038/s41598-017-17127-1
M3 - Article
VL - 7
SP - 17140-N/A
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
ER -