A non-synonymous polymorphism in galectin-3 lectin domain is associated with allergic reactions to beta-lactam antibiotics

J. A. Cornejo-García; Antonino Romano; R. M. Guéant-Rodríguez; A. Oussalah; N. Blanca-López; F. Gaeta; D. Tramoy; T. Josse; I. Doña; M. J. Torres; G. Canto; M. Blanca; J. L. Guéant

doi:10.1038/tpj.2015.24

A non-synonymous polymorphism in galectin-3 lectin domain is associated with allergic reactions to beta-lactam antibiotics

J. A. Cornejo-García, Antonino Romano, R. M. Guéant-Rodríguez, A. Oussalah, N. Blanca-López, F. Gaeta, D. Tramoy, T. Josse, I. Doña, M. J. Torres, G. Canto, M. Blanca, J. L. Guéant

Università Cattolica del Sacro Cuore

Risultato della ricerca: Contributo in rivista › Articolo in rivista

15 Citazioni (Scopus)

Abstract

Genetic predictors of beta-lactam (BL) allergy are mostly related to Immunoglobulin E (IgE) synthesis and atopy. Despite this context, little attention has been devoted to genes of IgE/FcɛRI pathway, such as galectin-3, a β-galactoside-binding lectin, which binds to IgE. We evaluated the association of LGALS3 polymorphisms with BL allergy in 395 Spanish and 198 Italian cases, compared with 310- and 339-matched controls, respectively. The rs11125 predicted BL allergy with an odds ratio of 4.0 in Spanish population (P<0.0001). This association was replicated with an odds ratio of 5.1 in Italian population (P<0.0001); rs11125 predicted also increased serum level of total IgE in Spanish controls. These data are consistent with the predicted deleterious influence of Gln>His substitution produced by rs11125 on galactose-binding activity of galectin-3. In conclusion, LGALS3 is the strongest genetic predictor of BL allergy reported so far. This association reflects the influence of genes of IgE/FcɛRI pathway in this pathology.

Lingua originale	English
pagine (da-a)	79-82
Numero di pagine	4
Rivista	Pharmacogenomics Journal
Volume	16
DOI	https://doi.org/10.1038/tpj.2015.24
Stato di pubblicazione	Pubblicato - 2016

Keywords

Drug allergy

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10.1038/tpj.2015.24

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Cornejo-García, J. A., Romano, A., Guéant-Rodríguez, R. M., Oussalah, A., Blanca-López, N., Gaeta, F., Tramoy, D., Josse, T., Doña, I., Torres, M. J., Canto, G., Blanca, M., & Guéant, J. L. (2016). A non-synonymous polymorphism in galectin-3 lectin domain is associated with allergic reactions to beta-lactam antibiotics. Pharmacogenomics Journal, 16, 79-82. https://doi.org/10.1038/tpj.2015.24

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title = "A non-synonymous polymorphism in galectin-3 lectin domain is associated with allergic reactions to beta-lactam antibiotics",

abstract = "Genetic predictors of beta-lactam (BL) allergy are mostly related to Immunoglobulin E (IgE) synthesis and atopy. Despite this context, little attention has been devoted to genes of IgE/FcɛRI pathway, such as galectin-3, a β-galactoside-binding lectin, which binds to IgE. We evaluated the association of LGALS3 polymorphisms with BL allergy in 395 Spanish and 198 Italian cases, compared with 310- and 339-matched controls, respectively. The rs11125 predicted BL allergy with an odds ratio of 4.0 in Spanish population (P<0.0001). This association was replicated with an odds ratio of 5.1 in Italian population (P<0.0001); rs11125 predicted also increased serum level of total IgE in Spanish controls. These data are consistent with the predicted deleterious influence of Gln>His substitution produced by rs11125 on galactose-binding activity of galectin-3. In conclusion, LGALS3 is the strongest genetic predictor of BL allergy reported so far. This association reflects the influence of genes of IgE/FcɛRI pathway in this pathology.",

keywords = "Drug allergy, Drug allergy",

author = "Cornejo-Garc{\'i}a, {J. A.} and Antonino Romano and Gu{\'e}ant-Rodr{\'i}guez, {R. M.} and A. Oussalah and N. Blanca-L{\'o}pez and F. Gaeta and D. Tramoy and T. Josse and I. Do{\~n}a and Torres, {M. J.} and G. Canto and M. Blanca and Gu{\'e}ant, {J. L.}",

year = "2016",

doi = "10.1038/tpj.2015.24",

language = "English",

volume = "16",

pages = "79--82",

journal = "Pharmacogenomics Journal",

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Cornejo-García, JA, Romano, A, Guéant-Rodríguez, RM, Oussalah, A, Blanca-López, N, Gaeta, F, Tramoy, D, Josse, T, Doña, I, Torres, MJ, Canto, G, Blanca, M & Guéant, JL 2016, 'A non-synonymous polymorphism in galectin-3 lectin domain is associated with allergic reactions to beta-lactam antibiotics', Pharmacogenomics Journal, vol. 16, pagg. 79-82. https://doi.org/10.1038/tpj.2015.24

TY - JOUR

T1 - A non-synonymous polymorphism in galectin-3 lectin domain is associated with allergic reactions to beta-lactam antibiotics

AU - Cornejo-García, J. A.

AU - Romano, Antonino

AU - Guéant-Rodríguez, R. M.

AU - Oussalah, A.

AU - Blanca-López, N.

AU - Gaeta, F.

AU - Tramoy, D.

AU - Josse, T.

AU - Doña, I.

AU - Torres, M. J.

AU - Canto, G.

AU - Blanca, M.

AU - Guéant, J. L.

PY - 2016

Y1 - 2016

N2 - Genetic predictors of beta-lactam (BL) allergy are mostly related to Immunoglobulin E (IgE) synthesis and atopy. Despite this context, little attention has been devoted to genes of IgE/FcɛRI pathway, such as galectin-3, a β-galactoside-binding lectin, which binds to IgE. We evaluated the association of LGALS3 polymorphisms with BL allergy in 395 Spanish and 198 Italian cases, compared with 310- and 339-matched controls, respectively. The rs11125 predicted BL allergy with an odds ratio of 4.0 in Spanish population (P<0.0001). This association was replicated with an odds ratio of 5.1 in Italian population (P<0.0001); rs11125 predicted also increased serum level of total IgE in Spanish controls. These data are consistent with the predicted deleterious influence of Gln>His substitution produced by rs11125 on galactose-binding activity of galectin-3. In conclusion, LGALS3 is the strongest genetic predictor of BL allergy reported so far. This association reflects the influence of genes of IgE/FcɛRI pathway in this pathology.

AB - Genetic predictors of beta-lactam (BL) allergy are mostly related to Immunoglobulin E (IgE) synthesis and atopy. Despite this context, little attention has been devoted to genes of IgE/FcɛRI pathway, such as galectin-3, a β-galactoside-binding lectin, which binds to IgE. We evaluated the association of LGALS3 polymorphisms with BL allergy in 395 Spanish and 198 Italian cases, compared with 310- and 339-matched controls, respectively. The rs11125 predicted BL allergy with an odds ratio of 4.0 in Spanish population (P<0.0001). This association was replicated with an odds ratio of 5.1 in Italian population (P<0.0001); rs11125 predicted also increased serum level of total IgE in Spanish controls. These data are consistent with the predicted deleterious influence of Gln>His substitution produced by rs11125 on galactose-binding activity of galectin-3. In conclusion, LGALS3 is the strongest genetic predictor of BL allergy reported so far. This association reflects the influence of genes of IgE/FcɛRI pathway in this pathology.

KW - Drug allergy

UR - http://hdl.handle.net/10807/72436

U2 - 10.1038/tpj.2015.24

DO - 10.1038/tpj.2015.24

M3 - Article

SN - 1470-269X

VL - 16

SP - 79

EP - 82

JO - Pharmacogenomics Journal

JF - Pharmacogenomics Journal

ER -

A non-synonymous polymorphism in galectin-3 lectin domain is associated with allergic reactions to beta-lactam antibiotics

Abstract

Keywords

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