A new therapeutic approach for the dry eye syndrome in patients with laryngopharyngeal reflux: First data

Giulio Cesare Passali, Alessandra Balestrazzi, Desiderio Passali, Valerio Damiani, Giorgio Ciprandi, Emilio Balestrazzi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

1 Citazioni (Scopus)

Abstract

Laryngopharyngeal reflux (LPR) is a common disorder. Pepsin has been detected also at eye level, this was a starting point for newest theories about LPR impact on Dry Eye Syndrome. The current preliminary study compared two treatments in patients with Dry Eye Syndrome and LPR. Patients were treated with Gastroftal eye drops and Gastroftal tablets or hyaluronic acid eye drops for 3 months. The following parameters were evaluated: Ocular Surface Disease Index (OSDI), OSDI categories, Reflux Symptom Index (RSI), Reflux Finding Score (RFS), Fluorescein Tear Breakup Time (B-TUT), and Schirmer test before and after treatment. On the whole, 21 patients were enrolled: 10 were treated with hyaluronic acid Atlantis (Group A) and 11 with Gastroftal eye drops and tablets (Group B). After treatment, in Group A only OSDI significantly diminished (p=0.029); in Group B there were significant reductions concerning OSDI (p=0.0277), OSDI categories (p=0.0211), RSI (p=0.0172), Schirmer test (p=0.0172), T-BUT (p=0.0265), and RFS (p=0.0205). The current preliminary demonstrated that the combined ocular and systemic therapy with hyaluronic acid, Magnesium alginate, Simethicone, and Camelia sinensis may be considered a promising treatment in patients with Dry Eye Syndrome due to LPR. (www.actabiomedica.it).
Lingua originaleEnglish
pagine (da-a)36-42
Numero di pagine7
RivistaACTA BIO-MEDICA DE L'ATENEO PARMENSE
Volume91
DOI
Stato di pubblicazionePubblicato - 2020

Keywords

  • Camelia sinensis
  • Dry eye syndrome
  • Eye reflux
  • Hyaluronic acid
  • Laryngopharyngeal reflux
  • Magnesium alginate
  • Simethicone

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