A new, striking morphological alteration of P-glycoprotein expression in NK cells from AIDS patients

Roberto Cauda, Mothanje Barbara Patricia Lucia, Luigi Ortona, G Rainaldi, G Donelli, W. Malorni

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Natural killer cells from healthy donors express P-glycoprotein on their surface. This molecule is rearranged during the process of cell-mediated cytotoxicity and it appears to be clustered in the cell-to-cell contact regions. By contrast, in HIV-infected subjects this rearrangement is hindered. These results seem to be associated with cytoskeleton network alterations of the cell-mediated killing process occurring in AIDS patients and can contribute to the comprehension of the mechanisms of the natural killer cell deficiency found in these patients.
Lingua originaleEnglish
pagine (da-a)19-21
Numero di pagine3
RivistaImmunology Letters
Stato di pubblicazionePubblicato - 2000

Keywords

  • AIDS
  • NK cells
  • p-glycoprotein

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