A Multicentric Prospective Incidence Study of Guillain-Barre Syndrome in Italy. the ITANG Study

M. D. Benedetti; M. Pugliatti; R. Dalessandro; E. Beghi; A. Chio; G. Logroscino; G. Filippini; F. Galeotti; M. Massari; C. Santuccio; R. Abruzzi L Raschetti; E Agazzi; E Agostoni; L Ambrogio; S Amidei; C Arbasino; V Argentiero; M Arnaboldi; D Baldini; R Barki; P Bassi; F Basso; V Belcastro; M Bellotti; E Bersano; R Besana; L Bettoni; G Bezzi; C Bianconi; M Bondavalli; A Bonometti; Borghi AM; C Borsato; S Bortolotto; Bottacchi EF; N Bresolin; S Bruno; A Burlina; G Cafasso; C Callegarini; A Calvo; E Candeloro; A Casano; Cattaneo SI; R Cavallo; A Cheldi; G Ciardo; F Cirignotta; Clerici AM; R Clerici; G Comi; R Conti; F Coppo; V Covelli; V Crespi; Dossi M Currò; Curtò NA; E D'Adda; C Dallocchio; S D'Anna; Massis P De; Toni Franceschini L De; Vito N Di; G Didonè; M Dileone; E Donati; M Dotta; R Fazio; F Federico; C Ferrarese; F Ferrazzini; B Ferrero; M Filosto; E Frasson; S Fusina; A Galbussera; E Gastaldo; C Geda; P Ghiglione; B Giometto; M Gionco; A Giorgetti; G Giussani; F Gobbin; G Grampa; E Granieri; G Greco; D Guidetti; C Guidi; M Guidotti; G Gusmaroli; D Imperiale; S Internò; S Jann; Spina I La; A Leo; M Leone; S Leoni; D Leotta; R Lerario; G Liotta; P Livrea; di Cortemiglio E Luda; B Maggio; E Magni; A Magnoni; J Maistrelli; D Manca; J Mandrioli; U Manera; N Marcello; P Marchi; C Marchini; S Marconi; M Mattioli; A Mauro; G Mazzaglia; D Medici; P Meineri; G Meola; G Micaglio; R Michelucci; G Michieli; G Micieli; C Minardi; C Moglia; S Monaco; E Montanari; G Moretto; V Munerati; G Mura; V Mussutto; C Nascimbene; W Neri; P Nichelli; E Nobile-Orazio; E Oddenino; S Onorato; A Padovani; M Palermo; Papurello DM; B Passarella; G Pavesi; Penza MT; M Perini; F Perini; F Perla; N Perlotto; P Perrone; P Pignatta; F Pisano; F Poglio; A Polo; M Poloni; D Porazzi; L Pradotto; P Previdi; R Quatrale; F Rasi; A Ravasio; C Ravetti; M Repaci; T Riccardi; P Riguzzi; R Rinaldi; M Riva; V Romeo; A Romorini; T Rosso; G Rotondo; T Sacquegna; F Sanson; V Santamato; D Santoro; V Sartori; F Sasanelli; K Savio; M Serena; V Silani; L Silvestri; V Simioni; Squintani GM; M Suardelli; L Tartagla; F Terenghi; E Terlizzi; Terzano MG; F Tesser; L Testa; A Ticca; N Ticozzi; M Tiriticco; Tola MR; S Tonietti; G Trianni; M Trojano; F Trotta; M Turatti; E Ursino; A Vanotti; M Vercellino; A Villani; E Vitelli; Marsala S Zambito; G Zanette; D Zarcone; G Zimatore; S. Zoccolella

doi:10.1159/000438752

A Multicentric Prospective Incidence Study of Guillain-Barre Syndrome in Italy. the ITANG Study

M. D. Benedetti, M. Pugliatti, R. Dalessandro, E. Beghi, A. Chio, G. Logroscino, G. Filippini, F. Galeotti, M. Massari, C. Santuccio, R. Abruzzi L Raschetti, E Agazzi, E Agostoni, L Ambrogio, S Amidei, C Arbasino, V Argentiero, M Arnaboldi, D Baldini, R BarkiP Bassi, F Basso, V Belcastro, M Bellotti, E Bersano, R Besana, L Bettoni, G Bezzi, C Bianconi, M Bondavalli, A Bonometti, Borghi AM, C Borsato, S Bortolotto, Bottacchi EF, N Bresolin, S Bruno, A Burlina, G Cafasso, C Callegarini, A Calvo, E Candeloro, A Casano, Cattaneo SI, R Cavallo, A Cheldi, G Ciardo, F Cirignotta, Clerici AM, R Clerici, G Comi, R Conti, F Coppo, V Covelli, V Crespi, Dossi M Currò, Curtò NA, E D'Adda, C Dallocchio, S D'Anna, Massis P De, Toni Franceschini L De, Vito N Di, G Didonè, M Dileone, E Donati, M Dotta, R Fazio, F Federico, C Ferrarese, F Ferrazzini, B Ferrero, M Filosto, E Frasson, S Fusina, A Galbussera, E Gastaldo, C Geda, P Ghiglione, B Giometto, M Gionco, A Giorgetti, G Giussani, F Gobbin, G Grampa, E Granieri, G Greco, D Guidetti, C Guidi, M Guidotti, G Gusmaroli, D Imperiale, S Internò, S Jann, Spina I La, A Leo, M Leone, S Leoni, D Leotta, R Lerario, G Liotta, P Livrea, di Cortemiglio E Luda, B Maggio, E Magni, A Magnoni, J Maistrelli, D Manca, J Mandrioli, U Manera, N Marcello, P Marchi, C Marchini, S Marconi, M Mattioli, A Mauro, G Mazzaglia, D Medici, P Meineri, G Meola, G Micaglio, R Michelucci, G Michieli, G Micieli, C Minardi, C Moglia, S Monaco, E Montanari, G Moretto, V Munerati, G Mura, V Mussutto, C Nascimbene, W Neri, P Nichelli, E Nobile-Orazio, E Oddenino, S Onorato, A Padovani, M Palermo, Papurello DM, B Passarella, G Pavesi, Penza MT, M Perini, F Perini, F Perla, N Perlotto, P Perrone, P Pignatta, F Pisano, F Poglio, A Polo, M Poloni, D Porazzi, L Pradotto, P Previdi, R Quatrale, F Rasi, A Ravasio, C Ravetti, M Repaci, T Riccardi, P Riguzzi, R Rinaldi, M Riva, V Romeo, A Romorini, T Rosso, G Rotondo, T Sacquegna, F Sanson, V Santamato, D Santoro, V Sartori, F Sasanelli, K Savio, M Serena, V Silani, L Silvestri, V Simioni, Squintani GM, M Suardelli, L Tartagla, F Terenghi, E Terlizzi, Terzano MG, F Tesser, L Testa, A Ticca, N Ticozzi, M Tiriticco, Tola MR, S Tonietti, G Trianni, M Trojano, F Trotta, M Turatti, E Ursino, A Vanotti, M Vercellino, A Villani, E Vitelli, Marsala S Zambito, G Zanette, D Zarcone, G Zimatore, S. Zoccolella

Risultato della ricerca: Contributo in rivista › Articolo

15 Citazioni (Scopus)

Abstract

To assess Guillain-Barre syndrome (GBS) incidence we relied on the Italian Network for the study of GBS (ITANG) established in 2010 in 7 Italian regions to analyse the association between influenza vaccination and GBS. Methods: All individuals aged ≥18 years, presenting with clinical manifestations that suggested GBS according to the universally accepted Asbury's diagnostic criteria (1990) were prospectively notified to a centralised database by ITANG neurologists over the period October 1, 2010-September 30, 2011. Through a telephone survey, 9 trained interviewers followed up the cases to diagnosis and then for 1 year since hospital discharge. Validation of case reporting was performed with the support of administrative data in 5 regions. Results: We found 365 cases fulfilling the definition for GBS or one of its variants over 19,846,068 population ≥18 years of age, yielding an annual incidence rate of 1.84 per 100,000 (95% CI 1.65-2.03), 2.30 (95% CI 1.99-2.60) in men and 1.41 (95% CI 1.18-1.64) in women. A highly significant peak of incidence was observed in February 2011 as compared to reference month (September 2011, rate ratio 3.3:1, p < 0.01). Conclusions: In Italy, GBS incidence was among the highest reported in Europe and higher than previously observed in Italian studies.

Lingua originale	Inglese
pagine (da-a)	90-99
Numero di pagine	10
Rivista	Neuroepidemiology
Volume	45
Numero di pubblicazione	2
DOI	https://doi.org/10.1159/000438752
Stato di pubblicazione	Pubblicato - 2015
Pubblicato esternamente	Sì

All Science Journal Classification (ASJC) codes

Epidemiologia
Neurologia (clinica)

Keywords

80 and over
Adult
Aged
Axonal and demyelinating GBS
Female
Guillain-Barre Syndrome
Guillain-Barré syndrome
Humans
Incidence
Italy
Male
Middle Aged
Prospective study
Trend
Young Adult

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Accesso al documento

10.1159/000438752

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Benedetti, M. D., Pugliatti, M., Dalessandro, R., Beghi, E., Chio, A., Logroscino, G., Filippini, G., Galeotti, F., Massari, M., Santuccio, C., Raschetti, R. A. L., Agazzi, E., Agostoni, E., Ambrogio, L., Amidei, S., Arbasino, C., Argentiero, V., Arnaboldi, M., Baldini, D., ... Zoccolella, S. (2015). A Multicentric Prospective Incidence Study of Guillain-Barre Syndrome in Italy. the ITANG Study. Neuroepidemiology, 45(2), 90-99. https://doi.org/10.1159/000438752

@article{3d49f54f3907449abbfa56d5b9a64cd6,

title = "A Multicentric Prospective Incidence Study of Guillain-Barre Syndrome in Italy. the ITANG Study",

abstract = "To assess Guillain-Barre syndrome (GBS) incidence we relied on the Italian Network for the study of GBS (ITANG) established in 2010 in 7 Italian regions to analyse the association between influenza vaccination and GBS. Methods: All individuals aged ≥18 years, presenting with clinical manifestations that suggested GBS according to the universally accepted Asbury's diagnostic criteria (1990) were prospectively notified to a centralised database by ITANG neurologists over the period October 1, 2010-September 30, 2011. Through a telephone survey, 9 trained interviewers followed up the cases to diagnosis and then for 1 year since hospital discharge. Validation of case reporting was performed with the support of administrative data in 5 regions. Results: We found 365 cases fulfilling the definition for GBS or one of its variants over 19,846,068 population ≥18 years of age, yielding an annual incidence rate of 1.84 per 100,000 (95% CI 1.65-2.03), 2.30 (95% CI 1.99-2.60) in men and 1.41 (95% CI 1.18-1.64) in women. A highly significant peak of incidence was observed in February 2011 as compared to reference month (September 2011, rate ratio 3.3:1, p < 0.01). Conclusions: In Italy, GBS incidence was among the highest reported in Europe and higher than previously observed in Italian studies.",

keywords = "80 and over, Adult, Aged, Axonal and demyelinating GBS, Female, Guillain-Barre Syndrome, Guillain-Barr{\'e} syndrome, Humans, Incidence, Italy, Male, Middle Aged, Prospective study, Trend, Young Adult, 80 and over, Adult, Aged, Axonal and demyelinating GBS, Female, Guillain-Barre Syndrome, Guillain-Barr{\'e} syndrome, Humans, Incidence, Italy, Male, Middle Aged, Prospective study, Trend, Young Adult",

author = "Benedetti, {M. D.} and M. Pugliatti and R. Dalessandro and E. Beghi and A. Chio and G. Logroscino and G. Filippini and F. Galeotti and M. Massari and C. Santuccio and Raschetti, {R. Abruzzi L} and E Agazzi and E Agostoni and L Ambrogio and S Amidei and C Arbasino and V Argentiero and M Arnaboldi and D Baldini and R Barki and P Bassi and F Basso and V Belcastro and M Bellotti and E Bersano and R Besana and L Bettoni and G Bezzi and C Bianconi and M Bondavalli and A Bonometti and Borghi AM and C Borsato and S Bortolotto and Bottacchi EF and N Bresolin and S Bruno and A Burlina and G Cafasso and C Callegarini and A Calvo and E Candeloro and A Casano and Cattaneo SI and R Cavallo and A Cheldi and G Ciardo and F Cirignotta and Clerici AM and R Clerici and G Comi and R Conti and F Coppo and V Covelli and V Crespi and Curr{\`o}, {Dossi M} and Curt{\`o} NA and E D'Adda and C Dallocchio and S D'Anna and De, {Massis P} and De, {Toni Franceschini L} and Di, {Vito N} and G Didon{\`e} and M Dileone and E Donati and M Dotta and R Fazio and F Federico and C Ferrarese and F Ferrazzini and B Ferrero and M Filosto and E Frasson and S Fusina and A Galbussera and E Gastaldo and C Geda and P Ghiglione and B Giometto and M Gionco and A Giorgetti and G Giussani and F Gobbin and G Grampa and E Granieri and G Greco and D Guidetti and C Guidi and M Guidotti and G Gusmaroli and D Imperiale and S Intern{\`o} and S Jann and La, {Spina I} and A Leo and M Leone and S Leoni and D Leotta and R Lerario and G Liotta and P Livrea and Luda, {di Cortemiglio E} and B Maggio and E Magni and A Magnoni and J Maistrelli and D Manca and J Mandrioli and U Manera and N Marcello and P Marchi and C Marchini and S Marconi and M Mattioli and A Mauro and G Mazzaglia and D Medici and P Meineri and G Meola and G Micaglio and R Michelucci and G Michieli and G Micieli and C Minardi and C Moglia and S Monaco and E Montanari and G Moretto and V Munerati and G Mura and V Mussutto and C Nascimbene and W Neri and P Nichelli and E Nobile-Orazio and E Oddenino and S Onorato and A Padovani and M Palermo and Papurello DM and B Passarella and G Pavesi and Penza MT and M Perini and F Perini and F Perla and N Perlotto and P Perrone and P Pignatta and F Pisano and F Poglio and A Polo and M Poloni and D Porazzi and L Pradotto and P Previdi and R Quatrale and F Rasi and A Ravasio and C Ravetti and M Repaci and T Riccardi and P Riguzzi and R Rinaldi and M Riva and V Romeo and A Romorini and T Rosso and G Rotondo and T Sacquegna and F Sanson and V Santamato and D Santoro and V Sartori and F Sasanelli and K Savio and M Serena and V Silani and L Silvestri and V Simioni and Squintani GM and M Suardelli and L Tartagla and F Terenghi and E Terlizzi and Terzano MG and F Tesser and L Testa and A Ticca and N Ticozzi and M Tiriticco and Tola MR and S Tonietti and G Trianni and M Trojano and F Trotta and M Turatti and E Ursino and A Vanotti and M Vercellino and A Villani and E Vitelli and Zambito, {Marsala S} and G Zanette and D Zarcone and G Zimatore and S. Zoccolella",

year = "2015",

doi = "10.1159/000438752",

language = "English",

volume = "45",

pages = "90--99",

journal = "Neuroepidemiology",

issn = "0251-5350",

publisher = "S. Karger AG",

number = "2",

}

Benedetti, MD, Pugliatti, M, Dalessandro, R, Beghi, E, Chio, A, Logroscino, G, Filippini, G, Galeotti, F, Massari, M, Santuccio, C, Raschetti, RAL, Agazzi, E, Agostoni, E, Ambrogio, L, Amidei, S, Arbasino, C, Argentiero, V, Arnaboldi, M, Baldini, D, Barki, R, Bassi, P, Basso, F, Belcastro, V, Bellotti, M, Bersano, E, Besana, R, Bettoni, L, Bezzi, G, Bianconi, C, Bondavalli, M, Bonometti, A, AM, B, Borsato, C, Bortolotto, S, EF, B, Bresolin, N, Bruno, S, Burlina, A, Cafasso, G, Callegarini, C, Calvo, A, Candeloro, E, Casano, A, SI, C, Cavallo, R, Cheldi, A, Ciardo, G, Cirignotta, F, AM, C, Clerici, R, Comi, G, Conti, R, Coppo, F, Covelli, V, Crespi, V, Currò, DM, NA, C, D'Adda, E, Dallocchio, C, D'Anna, S, De, MP, De, TFL, Di, VN, Didonè, G, Dileone, M, Donati, E, Dotta, M, Fazio, R, Federico, F, Ferrarese, C, Ferrazzini, F, Ferrero, B, Filosto, M, Frasson, E, Fusina, S, Galbussera, A, Gastaldo, E, Geda, C, Ghiglione, P, Giometto, B, Gionco, M, Giorgetti, A, Giussani, G, Gobbin, F, Grampa, G, Granieri, E, Greco, G, Guidetti, D, Guidi, C, Guidotti, M, Gusmaroli, G, Imperiale, D, Internò, S, Jann, S, La, SI, Leo, A, Leone, M, Leoni, S, Leotta, D, Lerario, R, Liotta, G, Livrea, P, Luda, DCE, Maggio, B, Magni, E, Magnoni, A, Maistrelli, J, Manca, D, Mandrioli, J, Manera, U, Marcello, N, Marchi, P, Marchini, C, Marconi, S, Mattioli, M, Mauro, A, Mazzaglia, G, Medici, D, Meineri, P, Meola, G, Micaglio, G, Michelucci, R, Michieli, G, Micieli, G, Minardi, C, Moglia, C, Monaco, S, Montanari, E, Moretto, G, Munerati, V, Mura, G, Mussutto, V, Nascimbene, C, Neri, W, Nichelli, P, Nobile-Orazio, E, Oddenino, E, Onorato, S, Padovani, A, Palermo, M, DM, P, Passarella, B, Pavesi, G, MT, P, Perini, M, Perini, F, Perla, F, Perlotto, N, Perrone, P, Pignatta, P, Pisano, F, Poglio, F, Polo, A, Poloni, M, Porazzi, D, Pradotto, L, Previdi, P, Quatrale, R, Rasi, F, Ravasio, A, Ravetti, C, Repaci, M, Riccardi, T, Riguzzi, P, Rinaldi, R, Riva, M, Romeo, V, Romorini, A, Rosso, T, Rotondo, G, Sacquegna, T, Sanson, F, Santamato, V, Santoro, D, Sartori, V, Sasanelli, F, Savio, K, Serena, M, Silani, V, Silvestri, L, Simioni, V, GM, S, Suardelli, M, Tartagla, L, Terenghi, F, Terlizzi, E, MG, T, Tesser, F, Testa, L, Ticca, A, Ticozzi, N, Tiriticco, M, MR, T, Tonietti, S, Trianni, G, Trojano, M, Trotta, F, Turatti, M, Ursino, E, Vanotti, A, Vercellino, M, Villani, A, Vitelli, E, Zambito, MS, Zanette, G, Zarcone, D, Zimatore, G & Zoccolella, S 2015, 'A Multicentric Prospective Incidence Study of Guillain-Barre Syndrome in Italy. the ITANG Study', Neuroepidemiology, vol. 45, n. 2, pagg. 90-99. https://doi.org/10.1159/000438752

TY - JOUR

T1 - A Multicentric Prospective Incidence Study of Guillain-Barre Syndrome in Italy. the ITANG Study

AU - Benedetti, M. D.

AU - Pugliatti, M.

AU - Dalessandro, R.

AU - Beghi, E.

AU - Chio, A.

AU - Logroscino, G.

AU - Filippini, G.

AU - Galeotti, F.

AU - Massari, M.

AU - Santuccio, C.

AU - Raschetti, R. Abruzzi L

AU - Agazzi, E

AU - Agostoni, E

AU - Ambrogio, L

AU - Amidei, S

AU - Arbasino, C

AU - Argentiero, V

AU - Arnaboldi, M

AU - Baldini, D

AU - Barki, R

AU - Bassi, P

AU - Basso, F

AU - Belcastro, V

AU - Bellotti, M

AU - Bersano, E

AU - Besana, R

AU - Bettoni, L

AU - Bezzi, G

AU - Bianconi, C

AU - Bondavalli, M

AU - Bonometti, A

AU - AM, Borghi

AU - Borsato, C

AU - Bortolotto, S

AU - EF, Bottacchi

AU - Bresolin, N

AU - Bruno, S

AU - Burlina, A

AU - Cafasso, G

AU - Callegarini, C

AU - Calvo, A

AU - Candeloro, E

AU - Casano, A

AU - SI, Cattaneo

AU - Cavallo, R

AU - Cheldi, A

AU - Ciardo, G

AU - Cirignotta, F

AU - AM, Clerici

AU - Clerici, R

AU - Comi, G

AU - Conti, R

AU - Coppo, F

AU - Covelli, V

AU - Crespi, V

AU - Currò, Dossi M

AU - NA, Curtò

AU - D'Adda, E

AU - Dallocchio, C

AU - D'Anna, S

AU - De, Massis P

AU - De, Toni Franceschini L

AU - Di, Vito N

AU - Didonè, G

AU - Dileone, M

AU - Donati, E

AU - Dotta, M

AU - Fazio, R

AU - Federico, F

AU - Ferrarese, C

AU - Ferrazzini, F

AU - Ferrero, B

AU - Filosto, M

AU - Frasson, E

AU - Fusina, S

AU - Galbussera, A

AU - Gastaldo, E

AU - Geda, C

AU - Ghiglione, P

AU - Giometto, B

AU - Gionco, M

AU - Giorgetti, A

AU - Giussani, G

AU - Gobbin, F

AU - Grampa, G

AU - Granieri, E

AU - Greco, G

AU - Guidetti, D

AU - Guidi, C

AU - Guidotti, M

AU - Gusmaroli, G

AU - Imperiale, D

AU - Internò, S

AU - Jann, S

AU - La, Spina I

AU - Leo, A

AU - Leone, M

AU - Leoni, S

AU - Leotta, D

AU - Lerario, R

AU - Liotta, G

AU - Livrea, P

AU - Luda, di Cortemiglio E

AU - Maggio, B

AU - Magni, E

AU - Magnoni, A

AU - Maistrelli, J

AU - Manca, D

AU - Mandrioli, J

AU - Manera, U

AU - Marcello, N

AU - Marchi, P

AU - Marchini, C

AU - Marconi, S

AU - Mattioli, M

AU - Mauro, A

AU - Mazzaglia, G

AU - Medici, D

AU - Meineri, P

AU - Meola, G

AU - Micaglio, G

AU - Michelucci, R

AU - Michieli, G

AU - Micieli, G

AU - Minardi, C

AU - Moglia, C

AU - Monaco, S

AU - Montanari, E

AU - Moretto, G

AU - Munerati, V

AU - Mura, G

AU - Mussutto, V

AU - Nascimbene, C

AU - Neri, W

AU - Nichelli, P

AU - Nobile-Orazio, E

AU - Oddenino, E

AU - Onorato, S

AU - Padovani, A

AU - Palermo, M

AU - DM, Papurello

AU - Passarella, B

AU - Pavesi, G

AU - MT, Penza

AU - Perini, M

AU - Perini, F

AU - Perla, F

AU - Perlotto, N

AU - Perrone, P

AU - Pignatta, P

AU - Pisano, F

AU - Poglio, F

AU - Polo, A

AU - Poloni, M

AU - Porazzi, D

AU - Pradotto, L

AU - Previdi, P

AU - Quatrale, R

AU - Rasi, F

AU - Ravasio, A

AU - Ravetti, C

AU - Repaci, M

AU - Riccardi, T

AU - Riguzzi, P

AU - Rinaldi, R

AU - Riva, M

AU - Romeo, V

AU - Romorini, A

AU - Rosso, T

AU - Rotondo, G

AU - Sacquegna, T

AU - Sanson, F

AU - Santamato, V

AU - Santoro, D

AU - Sartori, V

AU - Sasanelli, F

AU - Savio, K

AU - Serena, M

AU - Silani, V

AU - Silvestri, L

AU - Simioni, V

AU - GM, Squintani

AU - Suardelli, M

AU - Tartagla, L

AU - Terenghi, F

AU - Terlizzi, E

AU - MG, Terzano

AU - Tesser, F

AU - Testa, L

AU - Ticca, A

AU - Ticozzi, N

AU - Tiriticco, M

AU - MR, Tola

AU - Tonietti, S

AU - Trianni, G

AU - Trojano, M

AU - Trotta, F

AU - Turatti, M

AU - Ursino, E

AU - Vanotti, A

AU - Vercellino, M

AU - Villani, A

AU - Vitelli, E

AU - Zambito, Marsala S

AU - Zanette, G

AU - Zarcone, D

AU - Zimatore, G

AU - Zoccolella, S.

PY - 2015

Y1 - 2015

N2 - To assess Guillain-Barre syndrome (GBS) incidence we relied on the Italian Network for the study of GBS (ITANG) established in 2010 in 7 Italian regions to analyse the association between influenza vaccination and GBS. Methods: All individuals aged ≥18 years, presenting with clinical manifestations that suggested GBS according to the universally accepted Asbury's diagnostic criteria (1990) were prospectively notified to a centralised database by ITANG neurologists over the period October 1, 2010-September 30, 2011. Through a telephone survey, 9 trained interviewers followed up the cases to diagnosis and then for 1 year since hospital discharge. Validation of case reporting was performed with the support of administrative data in 5 regions. Results: We found 365 cases fulfilling the definition for GBS or one of its variants over 19,846,068 population ≥18 years of age, yielding an annual incidence rate of 1.84 per 100,000 (95% CI 1.65-2.03), 2.30 (95% CI 1.99-2.60) in men and 1.41 (95% CI 1.18-1.64) in women. A highly significant peak of incidence was observed in February 2011 as compared to reference month (September 2011, rate ratio 3.3:1, p < 0.01). Conclusions: In Italy, GBS incidence was among the highest reported in Europe and higher than previously observed in Italian studies.

AB - To assess Guillain-Barre syndrome (GBS) incidence we relied on the Italian Network for the study of GBS (ITANG) established in 2010 in 7 Italian regions to analyse the association between influenza vaccination and GBS. Methods: All individuals aged ≥18 years, presenting with clinical manifestations that suggested GBS according to the universally accepted Asbury's diagnostic criteria (1990) were prospectively notified to a centralised database by ITANG neurologists over the period October 1, 2010-September 30, 2011. Through a telephone survey, 9 trained interviewers followed up the cases to diagnosis and then for 1 year since hospital discharge. Validation of case reporting was performed with the support of administrative data in 5 regions. Results: We found 365 cases fulfilling the definition for GBS or one of its variants over 19,846,068 population ≥18 years of age, yielding an annual incidence rate of 1.84 per 100,000 (95% CI 1.65-2.03), 2.30 (95% CI 1.99-2.60) in men and 1.41 (95% CI 1.18-1.64) in women. A highly significant peak of incidence was observed in February 2011 as compared to reference month (September 2011, rate ratio 3.3:1, p < 0.01). Conclusions: In Italy, GBS incidence was among the highest reported in Europe and higher than previously observed in Italian studies.

KW - 80 and over

KW - Adult

KW - Aged

KW - Axonal and demyelinating GBS

KW - Female

KW - Guillain-Barre Syndrome

KW - Guillain-Barré syndrome

KW - Humans

KW - Incidence

KW - Italy

KW - Male

KW - Middle Aged

KW - Prospective study

KW - Trend

KW - Young Adult

KW - 80 and over

KW - Adult

KW - Aged

KW - Axonal and demyelinating GBS

KW - Female

KW - Guillain-Barre Syndrome

KW - Guillain-Barré syndrome

KW - Humans

KW - Incidence

KW - Italy

KW - Male

KW - Middle Aged

KW - Prospective study

KW - Trend

KW - Young Adult

UR - https://publicatt.unicatt.it/handle/10807/153016

UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84940768230&origin=inward

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84940768230&origin=inward

U2 - 10.1159/000438752

DO - 10.1159/000438752

M3 - Article

SN - 0251-5350

VL - 45

SP - 90

EP - 99

JO - Neuroepidemiology

JF - Neuroepidemiology

IS - 2

ER -

A Multicentric Prospective Incidence Study of Guillain-Barre Syndrome in Italy. the ITANG Study

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