TY - JOUR
T1 - A hemostasis study in CAPD patients during fibrinolytic intraperitoneal therapy with urokinase (UK)
AU - Strippoli, P
AU - Pilolli, D
AU - Mingrone, Geltrude
AU - Dimaggio, A
AU - Coviello, F
AU - Orbello, G
AU - Querques, M
AU - Scatizzi, A.
PY - 1989
Y1 - 1989
N2 - Catheter obstruction due to fibrin deposits during CAPD can cause poor outflow of peritoneal fluid and recurrent peritonitis. In order to treat this complication, 75,000 IU of diluted Urokinase (UK) were infused into catheters obstructed by fibrin in 10 CAPD patients (4 of which had peritonitis), without adverse reactions. After 60 minutes, a 2 liter exchange of peritoneal fluid was performed. In all the cases a normal outflow was restored. Hemostasis parameters (PT, PTT, TT, Fibrinogen, FDP, Fibrin monomers, BT, AT III) and blood cells count (RBC, HGB, HCT, WBC, PTL), were assayed before and two hours after the UK infusion, and did not show any significant variation, except for a decrease of white blood cells, which remained, however, within the normal range. No peritonitis episode occurred in the follow-up period. UK fibrinolytic therapy is safe and effective in treating fibrin obstruction of CAPD catheters without catheter removal and prevents recurrent peritonitis.
AB - Catheter obstruction due to fibrin deposits during CAPD can cause poor outflow of peritoneal fluid and recurrent peritonitis. In order to treat this complication, 75,000 IU of diluted Urokinase (UK) were infused into catheters obstructed by fibrin in 10 CAPD patients (4 of which had peritonitis), without adverse reactions. After 60 minutes, a 2 liter exchange of peritoneal fluid was performed. In all the cases a normal outflow was restored. Hemostasis parameters (PT, PTT, TT, Fibrinogen, FDP, Fibrin monomers, BT, AT III) and blood cells count (RBC, HGB, HCT, WBC, PTL), were assayed before and two hours after the UK infusion, and did not show any significant variation, except for a decrease of white blood cells, which remained, however, within the normal range. No peritonitis episode occurred in the follow-up period. UK fibrinolytic therapy is safe and effective in treating fibrin obstruction of CAPD catheters without catheter removal and prevents recurrent peritonitis.
KW - Catheters, Indwelling
KW - Female
KW - Fibrin
KW - Hemostasis
KW - Humans
KW - Infusions, Parenteral
KW - Kidney Failure, Chronic
KW - Male
KW - Peritoneal Dialysis, Continuous Ambulatory
KW - Peritonitis
KW - Recurrence
KW - Urokinase-Type Plasminogen Activator
KW - Catheters, Indwelling
KW - Female
KW - Fibrin
KW - Hemostasis
KW - Humans
KW - Infusions, Parenteral
KW - Kidney Failure, Chronic
KW - Male
KW - Peritoneal Dialysis, Continuous Ambulatory
KW - Peritonitis
KW - Recurrence
KW - Urokinase-Type Plasminogen Activator
UR - http://hdl.handle.net/10807/7187
M3 - Article
SN - 1197-8554
VL - 5
SP - 97
EP - 99
JO - ADVANCES IN PERITONEAL DIALYSIS
JF - ADVANCES IN PERITONEAL DIALYSIS
ER -