A) Helicobacter pylori, gastrointestinal symptoms, and metabolic control in young type 1 diabetes mellitus patients

Donato Rigante, Filippo Crea, Giovanni Battista Gasbarrini, Antonio Gasbarrini, Marcello Candelli, Giovanni Marietti, Enrico Celestino Nista, Alessandra Schiavino, Giulia Pignataro, Nicolo' Gentiloni Silveri, F Bartolozzi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

46 Citazioni (Scopus)

Abstract

OBJECTIVE: The role of Helicobacter pylori infection in metabolic control and gastrointestinal symptoms in type 1 diabetes mellitus (DM1) patients has been debated. The aim of this study was to investigate the prevalence of H pylori, of the more cytotoxic Cag-A-positive strains, and the effects of infection on gastrointestinal symptoms and metabolic control in young DM1 patients. Research Design and Methods. H pylori infection was investigated by using the 13C-urea breath test in 121 DM1 patients (65 males, 56 females; mean age: 15 +/- 6 years) and 147 matched controls. In positive patients, an assay for specific immunoglobulin G against Cag-A was performed. Glycosylated hemoglobin A, daily insulin requirement, and duration of illness were established; a questionnaire concerning the presence of dyspeptic symptoms was administered. RESULTS: No difference in H pylori infection rate between patients and controls was observed. Thirty-four (28.1%) of 121 patients and 43 (29.25%) of 147 controls were infected. Twenty-one patients and 24 controls were positive for Cag-A. Glycosylated hemoglobin A, daily insulin requirement, and duration of illness were not affected by infection nor by Cag-A status. Among gastrointestinal symptoms, only halitosis was related to H pylori infection, but this association disappeared after correction for age. Positive patients with halitosis showed a worse glycemic control than uninfected patients with halitosis. CONCLUSIONS: H pylori infection and Cag-A-positive strains do not affect metabolic control in DM1 patients. With regard to gastrointestinal symptoms studied, H pylori infection, when present in participants with halitosis, seems to predict a worse metabolic control than in H pylori-negative patients with halitosis.
Lingua originaleEnglish
pagine (da-a)800-803
Numero di pagine4
RivistaPediatrics
Stato di pubblicazionePubblicato - 2003

Keywords

  • diabetes
  • helicobacter pylori
  • metabolism

Fingerprint

Entra nei temi di ricerca di 'A) Helicobacter pylori, gastrointestinal symptoms, and metabolic control in young type 1 diabetes mellitus patients'. Insieme formano una fingerprint unica.

Cita questo