Abstract
The role of vasoactive intestinal peptide (VIP), as a possible neurotransmitter of the intrinsic nerve plexus in the guinea pig gallbladder, was investigated by monitoring spontaneous contractile activity. VIP receptor antagonist (4 Cl-D-Phe6, Leu 17)-VIP did not produce any effect on muscular tone and spontaneous activity, whereas (N-Ac-Tyr1, D-Phe2)-GRF-(1-29)-NH2, (14-GRF analog), which is known to stimulate digestive enzyme secretion by interacting with the VIP-preferring receptors, greatly increased the amplitude and frequency of waves as well as the muscular tone. Since VIP receptor antagonist acts selectively as a competitive antagonist for the action of VIP, we conclude that the gallbladder inhibitory intrinsic plexus neurotransmitter is not VIP, but a member of the glucagon-secretin family of peptides.
| Lingua originale | English |
|---|---|
| pagine (da-a) | 452-454 |
| Numero di pagine | 3 |
| Rivista | Experientia |
| Volume | 46 |
| Stato di pubblicazione | Pubblicato - 1990 |
Keywords
- Animals
- Female
- Gallbladder
- Glucagon
- Glucagon-Like Peptides
- Growth Hormone-Releasing Hormone
- Guinea Pigs
- Male
- Muscle Contraction
- Muscle, Smooth
- Neural Inhibition
- Neurotransmitter Agents
- Peptides
- Receptors, Gastrointestinal Hormone
- Receptors, Vasoactive Intestinal Peptide
- Secretin
- Sermorelin
- Vasoactive Intestinal Peptide