A glucagon-secretin-like peptide stimulates the intrinsic nervous plexus of guinea pig gallbladder

Geltrude Mingrone, Av Greco, R Mancinelli, C. Racanicchi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

The role of vasoactive intestinal peptide (VIP), as a possible neurotransmitter of the intrinsic nerve plexus in the guinea pig gallbladder, was investigated by monitoring spontaneous contractile activity. VIP receptor antagonist (4 Cl-D-Phe6, Leu 17)-VIP did not produce any effect on muscular tone and spontaneous activity, whereas (N-Ac-Tyr1, D-Phe2)-GRF-(1-29)-NH2, (14-GRF analog), which is known to stimulate digestive enzyme secretion by interacting with the VIP-preferring receptors, greatly increased the amplitude and frequency of waves as well as the muscular tone. Since VIP receptor antagonist acts selectively as a competitive antagonist for the action of VIP, we conclude that the gallbladder inhibitory intrinsic plexus neurotransmitter is not VIP, but a member of the glucagon-secretin family of peptides.
Lingua originaleEnglish
pagine (da-a)452-454
Numero di pagine3
RivistaExperientia
Volume46
Stato di pubblicazionePubblicato - 1990

Keywords

  • Animals
  • Female
  • Gallbladder
  • Glucagon
  • Glucagon-Like Peptides
  • Growth Hormone-Releasing Hormone
  • Guinea Pigs
  • Male
  • Muscle Contraction
  • Muscle, Smooth
  • Neural Inhibition
  • Neurotransmitter Agents
  • Peptides
  • Receptors, Gastrointestinal Hormone
  • Receptors, Vasoactive Intestinal Peptide
  • Secretin
  • Sermorelin
  • Vasoactive Intestinal Peptide

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