Abstract
| Lingua originale | English |
|---|---|
| pagine (da-a) | N/A-N/A |
| Rivista | Molecular Psychiatry |
| DOI | |
| Stato di pubblicazione | Pubblicato - 2014 |
Keywords
- Anorexia
- GWAS
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A genome-wide association study of anorexia nervosa. / Gambaro, Giovanni; Boraska, V.; Franklin, C. S.; Floyd, James A.B.; Thornton, L. M.; Huckins, L. M.; Southam, L.; Rayner, N. W.; Tachmazidou, I.; Klump, K. L.; Treasure, J.; Lewis, C. M.; Schmidt, U.; Tozzi, F.; Kiezebrink, K.; Hebebrand, J.; Gorwood, P.; Adan, R. A.H.; Kas, M. J.H.; Favaro, A.; Santonastaso, P.; Fernández-Aranda, F.; Gratacos, M.; Rybakowski, F.; Dmitrzak-Weglarz, M.; Kaprio, J.; Keski-Rahkonen, A.; Raevuori, A.; Van Furth, E. F.; Slof-Op 'T Landt, M. C.T.; Hudson, J. I.; Reichborn-Kjennerud, T.; Knudsen, G. P.S.; Monteleone, P.; Kaplan, A. S.; Karwautz, A.; Hakonarson, H.; Berrettini, W. H.; Guo, Y.; Li, D.; Schork, N. J.; Komaki, G.; Ando, T.; Inoko, H.; Esko, T.; Fischer, K.; Männik, K.; Metspalu, A.; Baker, J. H.; Cone, R. D.; Dackor, J.; Desocio, J. E.; Hilliard, C. E.; O'Toole, J. K.; Pantel, J.; Szatkiewicz, J. P.; Taico, C.; Zerwas, S.; Trace, S. E.; Davis, O. S.P.; Helder, S.; Bühren, K.; Burghardt, R.; De Zwaan, M.; Egberts, K.; Ehrlich, S.; Herpertz-Dahlmann, B.; Herzog, W.; Imgart, H.; Scherag, A.; Scherag, S.; Zipfel, S.; Boni, C.; Ramoz, N.; Versini, A.; Brandys, M. K.; Danner, U. N.; De Kovel, C.; Hendriks, J.; Koeleman, B. P.C.; Ophoff, R. A.; Strengman, E.; Van Elburg, A. A.; Bruson, A.; Clementi, M.; Degortes, D.; Forzan, M.; Tenconi, E.; Docampo, E.; Escaramís, G.; Jiménez-Murcia, S.; Lissowska, J.; Rajewski, A.; Szeszenia-Dabrowska, N.; Slopien, A.; Hauser, J.; Karhunen, L.; Meulenbelt, I.; Slagboom, P. E.; Tortorella, A.; Maj, M.; Dedoussis, G.; Dikeos, D.; Gonidakis, F.; Tziouvas, K.; Tsitsika, A.; Papezova, H.; Slachtova, L.; Martaskova, D.; Kennedy, J. L.; Levitan, R. D.; Yilmaz, Z.; Huemer, J.; Koubek, D.; Merl, E.; Wagner, G.; Lichtenstein, P.; Breen, G.; Cohen-Woods, S.; Farmer, A.; Mcguffin, P.; Cichon, S.; Giegling, I.; Herms, S.; Rujescu, D.; Schreiber, S.; Wichmann, H. E.; Dina, C.; Sladek, R.; Soranzo, Nicole; Julia, A.; Marsal, S.; Rabionet, R.; Gaborieau, V.; Dick, D. M.; Palotie, A.; Ripatti, S.; Widén, E.; Andreassen, O. A.; Espeseth, T.; Lundervold, A.; Reinvang, I.; Steen, V. M.; Le Hellard, S.; Mattingsdal, M.; Ntalla, I.; Bencko, V.; Foretova, L.; Janout, V.; Navratilova, M.; Gallinger, S.; Pinto, D.; Scherer, S. W.; Aschauer, H.; Carlberg, L.; Schosser, A.; Alfredsson, L.; Ding, B.; Klareskog, L.; Padyukov, L.; Courtet, P.; Guillaume, S.; Jaussent, I.; Finan, C.; Kalsi, G.; Roberts, M.; Logan, D. W.; Peltonen, Leena; Ritchie, G. R.S.; Barrett, Jeffrey C.; Anderson, Carl A.; Mcginnis, Ralph; Zeggini, Eleftheria; Sambrook, Jennifer; Stephens, Jonathan; Ouwehand, Willem H.; Mcardle, Wendy L.; Ring, Susan M.; Strachan, David P.; Alexander, Graeme; Bulik, Cynthia M.; Collier, David A.; Conlon, Peter J.; Dominiczak, Anna; Duncanson, Audrey; Hill, Adrian; Langford, Cordelia; Lord, Graham; Maxwell, Alexander P.; Morgan, Linda; Sandford, Richard N.; Sheerin, Neil; Vannberg, Fredrik O.; Blackburn, Hannah; Chen, Wei-Min; Edkins, Sarah; Gillman, Mathew; Gray, Emma; Hunt, Sarah E.; Onengut-Gumuscu, Suna; Potter, Simon; Rich, Stephen S.; Simpkin, Douglas; Whittaker, Pamela; Estivill, X.; Hinney, A.; Sullivan, P. F.
In: Molecular Psychiatry, 2014, pag. N/A-N/A.Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review
TY - JOUR
T1 - A genome-wide association study of anorexia nervosa
AU - Gambaro, Giovanni
AU - Boraska, V.
AU - Franklin, C. S.
AU - Floyd, James A.B.
AU - Thornton, L. M.
AU - Huckins, L. M.
AU - Southam, L.
AU - Rayner, N. W.
AU - Tachmazidou, I.
AU - Klump, K. L.
AU - Treasure, J.
AU - Lewis, C. M.
AU - Schmidt, U.
AU - Tozzi, F.
AU - Kiezebrink, K.
AU - Hebebrand, J.
AU - Gorwood, P.
AU - Adan, R. A.H.
AU - Kas, M. J.H.
AU - Favaro, A.
AU - Santonastaso, P.
AU - Fernández-Aranda, F.
AU - Gratacos, M.
AU - Rybakowski, F.
AU - Dmitrzak-Weglarz, M.
AU - Kaprio, J.
AU - Keski-Rahkonen, A.
AU - Raevuori, A.
AU - Van Furth, E. F.
AU - Slof-Op 'T Landt, M. C.T.
AU - Hudson, J. I.
AU - Reichborn-Kjennerud, T.
AU - Knudsen, G. P.S.
AU - Monteleone, P.
AU - Kaplan, A. S.
AU - Karwautz, A.
AU - Hakonarson, H.
AU - Berrettini, W. H.
AU - Guo, Y.
AU - Li, D.
AU - Schork, N. J.
AU - Komaki, G.
AU - Ando, T.
AU - Inoko, H.
AU - Esko, T.
AU - Fischer, K.
AU - Männik, K.
AU - Metspalu, A.
AU - Baker, J. H.
AU - Cone, R. D.
AU - Dackor, J.
AU - Desocio, J. E.
AU - Hilliard, C. E.
AU - O'Toole, J. K.
AU - Pantel, J.
AU - Szatkiewicz, J. P.
AU - Taico, C.
AU - Zerwas, S.
AU - Trace, S. E.
AU - Davis, O. S.P.
AU - Helder, S.
AU - Bühren, K.
AU - Burghardt, R.
AU - De Zwaan, M.
AU - Egberts, K.
AU - Ehrlich, S.
AU - Herpertz-Dahlmann, B.
AU - Herzog, W.
AU - Imgart, H.
AU - Scherag, A.
AU - Scherag, S.
AU - Zipfel, S.
AU - Boni, C.
AU - Ramoz, N.
AU - Versini, A.
AU - Brandys, M. K.
AU - Danner, U. N.
AU - De Kovel, C.
AU - Hendriks, J.
AU - Koeleman, B. P.C.
AU - Ophoff, R. A.
AU - Strengman, E.
AU - Van Elburg, A. A.
AU - Bruson, A.
AU - Clementi, M.
AU - Degortes, D.
AU - Forzan, M.
AU - Tenconi, E.
AU - Docampo, E.
AU - Escaramís, G.
AU - Jiménez-Murcia, S.
AU - Lissowska, J.
AU - Rajewski, A.
AU - Szeszenia-Dabrowska, N.
AU - Slopien, A.
AU - Hauser, J.
AU - Karhunen, L.
AU - Meulenbelt, I.
AU - Slagboom, P. E.
AU - Tortorella, A.
AU - Maj, M.
AU - Dedoussis, G.
AU - Dikeos, D.
AU - Gonidakis, F.
AU - Tziouvas, K.
AU - Tsitsika, A.
AU - Papezova, H.
AU - Slachtova, L.
AU - Martaskova, D.
AU - Kennedy, J. L.
AU - Levitan, R. D.
AU - Yilmaz, Z.
AU - Huemer, J.
AU - Koubek, D.
AU - Merl, E.
AU - Wagner, G.
AU - Lichtenstein, P.
AU - Breen, G.
AU - Cohen-Woods, S.
AU - Farmer, A.
AU - Mcguffin, P.
AU - Cichon, S.
AU - Giegling, I.
AU - Herms, S.
AU - Rujescu, D.
AU - Schreiber, S.
AU - Wichmann, H. E.
AU - Dina, C.
AU - Sladek, R.
AU - Soranzo, Nicole
AU - Julia, A.
AU - Marsal, S.
AU - Rabionet, R.
AU - Gaborieau, V.
AU - Dick, D. M.
AU - Palotie, A.
AU - Ripatti, S.
AU - Widén, E.
AU - Andreassen, O. A.
AU - Espeseth, T.
AU - Lundervold, A.
AU - Reinvang, I.
AU - Steen, V. M.
AU - Le Hellard, S.
AU - Mattingsdal, M.
AU - Ntalla, I.
AU - Bencko, V.
AU - Foretova, L.
AU - Janout, V.
AU - Navratilova, M.
AU - Gallinger, S.
AU - Pinto, D.
AU - Scherer, S. W.
AU - Aschauer, H.
AU - Carlberg, L.
AU - Schosser, A.
AU - Alfredsson, L.
AU - Ding, B.
AU - Klareskog, L.
AU - Padyukov, L.
AU - Courtet, P.
AU - Guillaume, S.
AU - Jaussent, I.
AU - Finan, C.
AU - Kalsi, G.
AU - Roberts, M.
AU - Logan, D. W.
AU - Peltonen, Leena
AU - Ritchie, G. R.S.
AU - Barrett, Jeffrey C.
AU - Anderson, Carl A.
AU - Mcginnis, Ralph
AU - Zeggini, Eleftheria
AU - Sambrook, Jennifer
AU - Stephens, Jonathan
AU - Ouwehand, Willem H.
AU - Mcardle, Wendy L.
AU - Ring, Susan M.
AU - Strachan, David P.
AU - Alexander, Graeme
AU - Bulik, Cynthia M.
AU - Collier, David A.
AU - Conlon, Peter J.
AU - Dominiczak, Anna
AU - Duncanson, Audrey
AU - Hill, Adrian
AU - Langford, Cordelia
AU - Lord, Graham
AU - Maxwell, Alexander P.
AU - Morgan, Linda
AU - Sandford, Richard N.
AU - Sheerin, Neil
AU - Vannberg, Fredrik O.
AU - Blackburn, Hannah
AU - Chen, Wei-Min
AU - Edkins, Sarah
AU - Gillman, Mathew
AU - Gray, Emma
AU - Hunt, Sarah E.
AU - Onengut-Gumuscu, Suna
AU - Potter, Simon
AU - Rich, Stephen S.
AU - Simpkin, Douglas
AU - Whittaker, Pamela
AU - Estivill, X.
AU - Hinney, A.
AU - Sullivan, P. F.
PY - 2014
Y1 - 2014
N2 - Anorexia nervosa (AN) is a complex and heritable eating disorder characterized by dangerously low body weight. Neither candidate gene studies nor an initial genome-wide association study (GWAS) have yielded significant and replicated results. We performed a GWAS in 2907 cases with AN from 14 countries (15 sites) and 14 860 ancestrally matched controls as part of the Genetic Consortium for AN (GCAN) and the Wellcome Trust Case Control Consortium 3 (WTCCC3). Individual association analyses were conducted in each stratum and meta-analyzed across all 15 discovery data sets. Seventy-six (72 independent) single nucleotide polymorphisms were taken forward for in silico (two data sets) or de novo (13 data sets) replication genotyping in 2677 independent AN cases and 8629 European ancestry controls along with 458 AN cases and 421 controls from Japan. The final global meta-analysis across discovery and replication data sets comprised 5551 AN cases and 21 080 controls. AN subtype analyses (1606 AN restricting; 1445 AN binge-purge) were performed. No findings reached genome-wide significance. Two intronic variants were suggestively associated: rs9839776 (P=3.01 × 10(-7)) in SOX2OT and rs17030795 (P=5.84 × 10(-6)) in PPP3CA. Two additional signals were specific to Europeans: rs1523921 (P=5.76 × 10(-)(6)) between CUL3 and FAM124B and rs1886797 (P=8.05 × 10(-)(6)) near SPATA13. Comparing discovery with replication results, 76% of the effects were in the same direction, an observation highly unlikely to be due to chance (P=4 × 10(-6)), strongly suggesting that true findings exist but our sample, the largest yet reported, was underpowered for their detection. The accrual of large genotyped AN case-control samples should be an immediate priority for the field.Molecular Psychiatry advance online publication, 11 February 2014; doi:10.1038/mp.2013.187.
AB - Anorexia nervosa (AN) is a complex and heritable eating disorder characterized by dangerously low body weight. Neither candidate gene studies nor an initial genome-wide association study (GWAS) have yielded significant and replicated results. We performed a GWAS in 2907 cases with AN from 14 countries (15 sites) and 14 860 ancestrally matched controls as part of the Genetic Consortium for AN (GCAN) and the Wellcome Trust Case Control Consortium 3 (WTCCC3). Individual association analyses were conducted in each stratum and meta-analyzed across all 15 discovery data sets. Seventy-six (72 independent) single nucleotide polymorphisms were taken forward for in silico (two data sets) or de novo (13 data sets) replication genotyping in 2677 independent AN cases and 8629 European ancestry controls along with 458 AN cases and 421 controls from Japan. The final global meta-analysis across discovery and replication data sets comprised 5551 AN cases and 21 080 controls. AN subtype analyses (1606 AN restricting; 1445 AN binge-purge) were performed. No findings reached genome-wide significance. Two intronic variants were suggestively associated: rs9839776 (P=3.01 × 10(-7)) in SOX2OT and rs17030795 (P=5.84 × 10(-6)) in PPP3CA. Two additional signals were specific to Europeans: rs1523921 (P=5.76 × 10(-)(6)) between CUL3 and FAM124B and rs1886797 (P=8.05 × 10(-)(6)) near SPATA13. Comparing discovery with replication results, 76% of the effects were in the same direction, an observation highly unlikely to be due to chance (P=4 × 10(-6)), strongly suggesting that true findings exist but our sample, the largest yet reported, was underpowered for their detection. The accrual of large genotyped AN case-control samples should be an immediate priority for the field.Molecular Psychiatry advance online publication, 11 February 2014; doi:10.1038/mp.2013.187.
KW - Anorexia
KW - GWAS
KW - Anorexia
KW - GWAS
UR - http://hdl.handle.net/10807/53882
U2 - 10.1038/mp.2013.187
DO - 10.1038/mp.2013.187
M3 - Article
SP - N/A-N/A
JO - Molecular Psychiatry
JF - Molecular Psychiatry
SN - 1359-4184
ER -