Abstract
| Lingua originale | English |
|---|---|
| pagine (da-a) | N/A-N/A |
| Rivista | Scientific Reports |
| Volume | 14 |
| DOI | |
| Stato di pubblicazione | Pubblicato - 2024 |
Keywords
- n/a
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In: Scientific Reports, Vol. 14, 2024, pag. N/A-N/A.
Risultato della ricerca: Contributo in rivista › Articolo in rivista
TY - JOUR
T1 - A genome-wide association study for survival from a multi-centre European study identified variants associated with COVID-19 risk of death
AU - Minnai, Francesca
AU - Biscarini, Filippo
AU - Esposito, Martina
AU - Dragani, Tommaso A.
AU - Bujanda, Luis
AU - Rahmouni, Souad
AU - Alarcón-Riquelme, Marta E.
AU - Bernardo, David
AU - Carnero-Montoro, Elena
AU - Buti, Maria
AU - Zeberg, Hugo
AU - Asselta, Rosanna
AU - Romero-Gómez, Manuel
AU - Fernandez-Cadenas, Israel
AU - Fallerini, Chiara
AU - Zguro, Kristina
AU - Croci, Susanna
AU - Baldassarri, Margherita
AU - Bruttini, Mirella
AU - Furini, Simone
AU - Renieri, Alessandra
AU - Colombo, Francesca
AU - Mari, Francesca
AU - Daga, Sergio
AU - Meloni, Ilaria
AU - Brunelli, Giulia
AU - Lista, Mirjam
AU - Maffeo, Debora
AU - Pasquinelli, Elena
AU - Antolini, Enrica
AU - Basso, Simona Letizia
AU - Minetto, Samantha
AU - Rollo, Giulia
AU - Rina, Angela
AU - Rozza, Martina
AU - Tita, Rossella
AU - Mencarelli, Maria Antonietta
AU - Rizzo, Caterina Lo
AU - Pinto, Anna Maria
AU - Ariani, Francesca
AU - Montagnani, Francesca
AU - Tumbarello, Mario
AU - Rancan, Ilaria
AU - Fabbiani, Massimiliano
AU - Cameli, Paolo
AU - Bennett, David
AU - Anedda, Federico
AU - Marcantonio, Simona
AU - Scolletta, Sabino
AU - Franchi, Federico
AU - Franchi, Francesca
AU - Mazzei, Maria Antonietta
AU - Guerrini, Susanna
AU - Conticini, Edoardo
AU - Cantarini, Luca
AU - Frediani, Bruno
AU - Tacconi, Danilo
AU - Raffaelli, Chiara Spertilli
AU - Emiliozzi, Arianna
AU - Feri, Marco
AU - Donati, Alice
AU - Scala, Raffaele
AU - Guidelli, Luca
AU - Spargi, Genni
AU - Corridi, Marta
AU - Nencioni, Cesira
AU - Croci, Leonardo
AU - Caldarelli, Gian Piero
AU - Romani, Davide
AU - Piacentini, Paolo
AU - Bandini, Maria
AU - Desanctis, Elena
AU - Cappelli, Silvia
AU - Canaccini, Anna
AU - Verzuri, Agnese
AU - Anemoli, Valentina
AU - Ognibene, Agostino
AU - Lorubbio, Maria
AU - Pancrazzi, Alessandro
AU - Vaghi, Massimo
AU - Monforte, Antonella D.’Arminio
AU - Miraglia, Federica Gaia
AU - Mondelli, Mario U.
AU - Mantovani, Stefania
AU - Bruno, Raffaele
AU - Vecchia, Marco
AU - Maffezzoni, Marcello
AU - Martinelli, Enrico
AU - Girardis, Massimo
AU - Busani, Stefano
AU - Venturelli, Sophie
AU - Cossarizza, Andrea
AU - Antinori, Andrea
AU - Antinori, Armando
AU - Vergori, Alessandra
AU - Rusconi, Stefano
AU - Siano, Matteo
AU - Gabrieli, Arianna
AU - Riva, Agostino
AU - Francisci, Daniela
AU - Schiaroli, Elisabetta
AU - Pallotto, Carlo
AU - Parisi, Saverio Giuseppe
AU - Basso, Monica
AU - Panese, Sandro
AU - Baratti, Stefano
AU - Scotton, Pier Giorgio
AU - Andretta, Francesca
AU - Giobbia, Mario
AU - Scaggiante, Renzo
AU - Gatti, Francesca
AU - Castelli, Francesco
AU - Quiros-Roldan, Eugenia
AU - Antoni, Melania Degli
AU - Zanella, Isabella
AU - Monica, Matteo Della
AU - Piscopo, Carmelo
AU - Capasso, Mario
AU - Capasso, Monica
AU - Russo, Roberta
AU - Andolfo, Immacolata
AU - Iolascon, Achille
AU - Fiorentino, Giuseppe
AU - Carella, Massimo
AU - Castori, Marco
AU - Merla, Giuseppe
AU - Squeo, Gabriella Maria
AU - Aucella, Filippo
AU - Raggi, Pamela
AU - Perna, Rita
AU - Bassetti, Matteo
AU - Di Biagio, Antonio
AU - Di Biagio, Anna
AU - Sanguinetti, Maurizio
AU - Masucci, Luca
AU - Guarnaccia, Alessandra
AU - Valente, Serafina
AU - Di Florio, Alex
AU - Mandalà, Marco
AU - Giorli, Alessia
AU - Salerni, Lorenzo
AU - Zucchi, Patrizia
AU - Parravicini, Pierpaolo
AU - Menatti, Elisabetta
AU - Trotta, Tullio
AU - Giannattasio, Ferdinando
AU - Coiro, Gabriella
AU - Lacerenza, Gianluca
AU - Mussini, Cristina
AU - Tavecchia, Luisa
AU - Crotti, Lia
AU - Parati, Gianfranco
AU - Menè, Roberto
AU - Sanarico, Maurizio
AU - Gori, Marco
AU - Gori, Mario
AU - Raimondi, Francesco
AU - Stella, Alessandra
AU - Biscarini, Filippo
AU - Bachetti, Tiziana
AU - La Rovere, Maria Teresa
AU - Bussotti, Maurizio
AU - Ludovisi, Serena
AU - Capitani, Katia
AU - Dei, Simona
AU - Ravaglia, Sabrina
AU - Giliberti, Annarita
AU - Gori, Giulia
AU - Artuso, Rosangela
AU - Andreucci, Elena
AU - Perrella, Antonio
AU - Bianchi, Francesco
AU - Bergomi, Paola
AU - Catena, Emanuele
AU - Colombo, Riccardo
AU - Luchi, Sauro
AU - Morelli, Giovanna
AU - Petrocelli, Paola
AU - Iacopini, Sarah
AU - Modica, Sara
AU - Baroni, Silvia
AU - Micheli, Giulia
AU - Falcone, Marco
AU - Urso, Donato
AU - Tiseo, Giusy
AU - Matucci, Tommaso
AU - Pulcinelli, Alice
AU - Grassi, Davide
AU - Ferri, Claudio
AU - Marinangeli, Franco
AU - Brancati, Francesco
AU - Vincenti, Antonella
AU - Borgo, Valentina
AU - Lombardi, Stefania
AU - Lenzi, Mirco
AU - Di Pietro, Massimo Antonio
AU - Di Pietro, Maria Luisa
AU - Attala, Letizia
AU - Costa, Cecilia
AU - Gabbuti, Andrea
AU - Bellucci, Alessio
AU - Colaneri, Marta
AU - Casprini, Patrizia
AU - Pomara, Cristoforo
AU - Esposito, Massimiliano
AU - Leoncini, Roberto
AU - Cirianni, Michele
AU - Galasso, Lucrezia
AU - Bellini, Marco Antonio
AU - Gabbi, Chiara
AU - Picchiotti, Nicola
AU - Furini, Simone
AU - Pelo, Elisabetta
AU - Minuti, Barbara
AU - Gerundino, Francesca
AU - Lazzeri, Chiara
AU - Vecchi, Arianna
AU - Bianchi, Leila
AU - Venturini, Elisabetta
AU - Venturini, Elena
AU - Montagnani, Carlotta
AU - Chiappini, Elena
AU - Beltrami, Cristina
AU - Galli, Luisa
PY - 2024
Y1 - 2024
N2 - The clinical manifestations of SARS-CoV-2 infection vary widely among patients, from asymptomatic to life-threatening. Host genetics is one of the factors that contributes to this variability as previously reported by the COVID-19 Host Genetics Initiative (HGI), which identified sixteen loci associated with COVID-19 severity. Herein, we investigated the genetic determinants of COVID-19 mortality, by performing a case-only genome-wide survival analysis, 60 days after infection, of 3904 COVID-19 patients from the GEN-COVID and other European series (EGAS00001005304 study of the COVID-19 HGI). Using imputed genotype data, we carried out a survival analysis using the Cox model adjusted for age, age2, sex, series, time of infection, and the first ten principal components. We observed a genome-wide significant (P-value < 5.0 × 10−8) association of the rs117011822 variant, on chromosome 11, of rs7208524 on chromosome 17, approaching the genome-wide threshold (P-value = 5.19 × 10−8). A total of 113 variants were associated with survival at P-value < 1.0 × 10−5 and most of them regulated the expression of genes involved in immune response (e.g., CD300 and KLR genes), or in lung repair and function (e.g., FGF19 and CDH13). Overall, our results suggest that germline variants may modulate COVID-19 risk of death, possibly through the regulation of gene expression in immune response and lung function pathways.
AB - The clinical manifestations of SARS-CoV-2 infection vary widely among patients, from asymptomatic to life-threatening. Host genetics is one of the factors that contributes to this variability as previously reported by the COVID-19 Host Genetics Initiative (HGI), which identified sixteen loci associated with COVID-19 severity. Herein, we investigated the genetic determinants of COVID-19 mortality, by performing a case-only genome-wide survival analysis, 60 days after infection, of 3904 COVID-19 patients from the GEN-COVID and other European series (EGAS00001005304 study of the COVID-19 HGI). Using imputed genotype data, we carried out a survival analysis using the Cox model adjusted for age, age2, sex, series, time of infection, and the first ten principal components. We observed a genome-wide significant (P-value < 5.0 × 10−8) association of the rs117011822 variant, on chromosome 11, of rs7208524 on chromosome 17, approaching the genome-wide threshold (P-value = 5.19 × 10−8). A total of 113 variants were associated with survival at P-value < 1.0 × 10−5 and most of them regulated the expression of genes involved in immune response (e.g., CD300 and KLR genes), or in lung repair and function (e.g., FGF19 and CDH13). Overall, our results suggest that germline variants may modulate COVID-19 risk of death, possibly through the regulation of gene expression in immune response and lung function pathways.
KW - n/a
KW - n/a
UR - http://hdl.handle.net/10807/306242
U2 - 10.1038/s41598-024-53310-x
DO - 10.1038/s41598-024-53310-x
M3 - Article
SN - 2045-2322
VL - 14
SP - N/A-N/A
JO - Scientific Reports
JF - Scientific Reports
ER -