A fully-automated neural network analysis of AFM force-distance curves for cancer tissue diagnosis

Gabriele Ciasca, Massimiliano Papi, Giuseppe Maulucci, Marco De Spirito, Eleonora Minelli, Valentina Palmieri, Tanya Enny Sassun, Manila Antonelli, Antonio Santoro, Felice Giangaspero, Roberto Delfini, Gaetano Campi

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

22 Citazioni (Scopus)

Abstract

Atomic Force Microscopy (AFM) has the unique capability of probing the nanoscale mechanical properties of biological systems that affect and are affected by the occurrence of many pathologies, including cancer. This capability has triggered growing interest in the translational process of AFM from physics laboratories to clinical practice. A factor still hindering the current use of AFM in diagnostics is related to the complexity of AFM data analysis, which is time-consuming and needs highly specialized personnel with a strong physical and mathematical background. In this work, we demonstrate an operator-independent neural-network approach for the analysis of surgically removed brain cancer tissues. This approach allowed us to distinguish - in a fully automated fashion - cancer from healthy tissues with high accuracy, also highlighting the presence and the location of infiltrating tumor cells.
Lingua originaleEnglish
pagine (da-a)1-5
Numero di pagine5
RivistaApplied Physics Letters
Volume111
DOI
Stato di pubblicazionePubblicato - 2017

Keywords

  • Physics and Astronomy (miscellaneous)

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