A field strength independent MR radiomics model to predict pathological complete response in locally advanced rectal cancer

Maria Antonietta Gambacorta, Luigi Azario, Vincenzo Valentini, Davide Cusumano, Jacopo Lenkowicz, Giuditta Chiloiro, Luca Boldrini, Carlotta Masciocchi, Nicola Dinapoli, Roberto Gatta, Andrea Damiani, Gert Meijer, Martijn Intven

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Purpose: Aim of this study was to develop a generalised radiomics model for predicting pathological complete response after neoadjuvant chemo-radiotherapy in locally advanced rectal cancer patients using pre-CRT T2-weighted images acquired at a 1.5 T and a 3 T scanner. Methods: In two institutions, 195 patients were scanned: 136 patients were scanned on a 1.5 T MR scanner, 59 patients on a 3 T MR scanner. Gross tumour volumes were delineated on the MR images and 496 radiomic features were extracted, applying the intensity-based (IB) filter. Features were standardised with Z-score normalisation and an initial feature selection was carried out using Wilcoxon–Mann–Whitney test: The most significant features at 1.5 T and 3 T were selected as main features. Several logistic regression models combining the main features with a third one selected by those resulting significant were elaborated and evaluated in terms of area under curve (AUC). A tenfold cross-validation was repeated 300 times to evaluate the model robustness. Results: Three features were selected: maximum fractal dimension with IB = 0–50, energy and grey-level non-uniformity calculated on the run-length matrix with IB = 0–50. The AUC of the model applied to the whole dataset after cross-validation was 0.72, while values of 0.70 and 0.83 were obtained when 1.5 T and 3 T patients were considered, respectively. Conclusions: The model elaborated showed good performance, even when data from patients scanned on 1.5 T and 3 T were merged. This shows that magnetic field intensity variability can be overcome by means of selecting appropriate image features.
Lingua originaleEnglish
pagine (da-a)421-429
Numero di pagine9
RivistaLA RADIOLOGIA MEDICA
Volume126
DOI
Stato di pubblicazionePubblicato - 2021

Keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • Algorithms
  • Area Under Curve
  • Chemoradiotherapy, Adjuvant
  • Female
  • Fractals
  • Humans
  • Inter-scanner variability
  • Logistic Models
  • Magnetic Resonance Imaging
  • Magnetic field intensity
  • Magnetic resonance imaging
  • Male
  • Middle Aged
  • Models, Theoretical
  • Radiomics
  • Rectal Neoplasms
  • Rectal cancer
  • Retrospective Studies
  • Statistics, Nonparametric
  • Treatment Outcome
  • Tumor Burden

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