A false positive case of high-sensitivity cardiac troponin in a patient with acute chest pain: Analytical study of the interference.

Silvia Baroni, Eliana Troiani, Concetta Santonocito, Giacomo Moretti, Carmen De Luca, Mirca Antenucci, Andrea Urbani

Risultato della ricerca: Contributo in rivistaArticolo

3 Citazioni (Scopus)

Abstract

We report a case of a heterophile antibodies interference in a new high-sensitivity troponin commercial immunoassay (cTNIH Siemens), observed in a patient with possible acute coronary syndrome (ACS). The analytical interference was investigated with standard laboratories procedures. The false positive result was found with different troponin methods and kits. We also investigated the protein sequence of cTnl and no sequence variants were detected. The discordance between clinical pictures and high concentration of cTnl, together with the collaboration between clinicians and laboratory staff avoided possible erroneous diagnosis and further invasive investigations to the patient.
Lingua originaleInglese
pagine (da-a)103-105
Numero di pagine3
RivistaClinical Biochemistry
DOI
Stato di pubblicazionePubblicato - 2019

Keywords

  • Cardiac troponin
  • Heterophile antibodies
  • Immunoassay
  • Interference

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