Abstract
We report a case of a heterophile antibodies interference in a new high-sensitivity troponin commercial immunoassay
(cTNIH Siemens), observed in a patient with possible acute coronary syndrome (ACS). The analytical
interference was investigated with standard laboratories procedures. The false positive result was found with
different troponin methods and kits. We also investigated the protein sequence of cTnl and no sequence variants
were detected. The discordance between clinical pictures and high concentration of cTnl, together with the
collaboration between clinicians and laboratory staff avoided possible erroneous diagnosis and further invasive
investigations to the patient.
Lingua originale | Inglese |
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pagine (da-a) | 103-105 |
Numero di pagine | 3 |
Rivista | Clinical Biochemistry |
DOI | |
Stato di pubblicazione | Pubblicato - 2019 |
Keywords
- Cardiac troponin
- Heterophile antibodies
- Immunoassay
- Interference