A false positive case of high-sensitivity cardiac troponin in a patient with acute chest pain: Analytical study of the interference.

Silvia Baroni, Concetta Santonocito, Andrea Urbani, Eliana Troiani, Giacomo Moretti, Carmen De Luca, Mirca Antenucci

Risultato della ricerca: Contributo in rivistaArticolo in rivista

3 Citazioni (Scopus)

Abstract

We report a case of a heterophile antibodies interference in a new high-sensitivity troponin commercial immunoassay (cTNIH Siemens), observed in a patient with possible acute coronary syndrome (ACS). The analytical interference was investigated with standard laboratories procedures. The false positive result was found with different troponin methods and kits. We also investigated the protein sequence of cTnl and no sequence variants were detected. The discordance between clinical pictures and high concentration of cTnl, together with the collaboration between clinicians and laboratory staff avoided possible erroneous diagnosis and further invasive investigations to the patient.
Lingua originaleEnglish
pagine (da-a)103-105
Numero di pagine3
RivistaClinical Biochemistry
Stato di pubblicazionePubblicato - 2019

Keywords

  • Cardiac troponin
  • Heterophile antibodies
  • Immunoassay
  • Interference

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