A facile and regioselective multicomponent synthesis of chiral aryl-1,2-mercaptoamines in water followed by monoamine oxidase (MAO-N) enzymatic resolution

Domiziana Masci, Kate Lauder, Anita Toscani, Aya Al Mekdad, Gary W. Black, Nicola L. Brown, Nicholas J. Turner, Renzo Luisi, Daniele Castagnolo

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

Abstract

A facile microwave assisted three-component protocol allows the synthesis of chiral aryl-1,2-mercaptoamines in water in a few minutes with high yields, bypassing the use of toxic aziridine intermediates. The chiral 1,2-mercaptoamines were then deracemized through enzymatic resolution of the racemates using monoamine oxidase (MAO-N) biocatalysts.
Lingua originaleEnglish
pagine (da-a)8982-8986
Numero di pagine5
RivistaORGANIC & BIOMOLECULAR CHEMISTRY
Volume17
DOI
Stato di pubblicazionePubblicato - 2019

Keywords

  • Aryl-1,2-mercaptoamines
  • Chirality
  • Green approach
  • Monoamine oxidase biocatalysts
  • One-pot microwave-mediated synthesis
  • Water

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