A CREB-Sirt1-Hes1 Circuitry Mediates Neural Stem Cell Response to Glucose Availability

Salvatore Fusco, Lucia Leone, Roberto Piacentini, Giuseppe Maulucci, Giovambattista Pani, Claudio Grassi, Saviana Antonella Barbati, Daniela Maria Samengo, Matteo Spinelli, Gabriele Toietta, Michael Mcburney

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

43 Citazioni (Scopus)

Abstract

Adult neurogenesis plays increasingly recognized roles in brain homeostasis and repair and is profoundly affected by energy balance and nutrients. We found that the expression of Hes-1 (hairy and enhancer of split 1) is modulated in neural stem and progenitor cells (NSCs) by extracellular glucose through the coordinated action of CREB (cyclic AMP responsive element binding protein) and Sirt-1 (Sirtuin 1), two cellular nutrient sensors. Excess glucose reduced CREB-activated Hes-1 expression and results in impaired cell proliferation. CREB-deficient NSCs expanded poorly in vitro and did not respond to glucose availability. Elevated glucose also promoted Sirt-1-dependent repression of the Hes-1 promoter. Conversely, in low glucose, CREB replaced Sirt-1 on the chromatin associated with the Hes-1 promoter enhancing Hes-1 expression and cell proliferation. Thus, the glucose-regulated antagonism between CREB and Sirt-1 for Hes-1 transcription participates in the metabolic regulation of neurogenesis.
Lingua originaleEnglish
pagine (da-a)1195-1205
Numero di pagine11
RivistaCell Reports
Volume2016
DOI
Stato di pubblicazionePubblicato - 2016

Keywords

  • CREB
  • Sirt-1
  • adult neurogenesis
  • diabetes
  • metabolism
  • neural stem cells
  • nutrients

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